Figure 1D: Biphasic control can resist mutant invasion of feedback circuits.
D An arrow marks the time when a mutant with a strong activation of the sensing of y arises (for the circuit depicted in B). This mutant has a selective advantage and
takes over the population.
SED-ML simulation
https://jjj.bio.vu.nl/models/experiments/karin2017_fig1d/simulate
SEEK ID: https://fairdomhub.org/studies/384
Karin et al (2017) Molecular Systems Biology
Projects: Molecular Systems Biology
Experimentalists: Not specified
Export PNG
Download
Contributor and Creators
Views: 640
Created: 31st Jul 2018 at 11:53
Last updated: 31st Jul 2018 at 12:04
Related items
Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, School of Computer Science, University of Manchester, Stellenbosch University
The Molecular Systems Biology project holds information for reproducing simulation figures in the journal. This can include experimental data files, model files and manuscript information.
Programme: Journals
Public web page: http://msb.embopress.org
Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits
Snapshots: No snapshots
