Using optical tweezers to position yeast cells in a microfluidic chamber, we were able to observe sustained oscillations in individual isolated cells. Using a detailed kinetic model for the cellular reactions, we simulated the heterogeneity in the response of the individual cells, assuming small differences in a single internal parameter. By operating at two different flow rates per experiment, we observe four of categories of cell behaviour. The present model (gustavsson1) predicts the limit cycles observed in 16.7% of the cell population at both flow rates.
SEEK ID: https://fairdomhub.org/models/84?version=3
1 item is associated with this Model:Organism: Saccharomyces cerevisiae
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Execution or visualisation environment: JWS Online
Model image: No image specified
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David D van Niekerk
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Created: 23rd Jul 2012 at 21:39
Last updated: 23rd Jul 2012 at 23:53
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Version 3 (latest) Created 23rd Jul 2012 at 23:53 by Franco du Preez
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Projects: SysMO DB
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester
Expertise: Glycolysis, Limit cycle oscillations
Tools: Java, Mathematica
Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications, SCyCode The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers, Project Coordination, WP 3: Drug release kinetics study, Glucose metabolism in cancer cell lines
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, University of Manchester - Department of Computer Science, Stellenbosch University
SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".
The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.
Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...
Projects: BaCell-SysMO, COSMIC, SUMO, KOSMOBAC, SysMO-LAB, PSYSMO, SCaRAB, MOSES, TRANSLUCENT, STREAM, SulfoSys, SysMO DB, SysMO Funders, SilicoTryp, Noisy-Strep
Web page: http://sysmo.net/
The main objectives of SysMO-DB are to: facilitate the web-based exchange of data between research groups within- and inter- consortia, and to provide an integrated platform for the dissemination of the results of the SysMO projects to the scientific community. We aim to devise a progressive and scalable solution to the data management needs of the SysMO initiative, that:
- facilitates and maximises the potential for data exchange between SysMO research groups;
- maximises the ‘shelf life’ and ...
Programme: SysMO
Public web page: http://www.sysmo-db.org/
Organisms: Not specified
Investigating oscillations at the level of yeast populations and individual cells
Submitter: Katy Wolstencroft
Studies: Detailed kinetics of yeast glycolytic oscillation, Sustained glycolytic oscillations in individual isolated yeast cells
Assays: Detailed kinetic model of yeast glycolytic oscillation, Metabolite concentrations in yeast glycolytic oscillations, Modelling sustained glycolytic oscillations in individual isolated yeast...
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Submitter: Katy Wolstencroft
Investigation: Yeast Glycolytic Oscillations
Assays: Modelling sustained glycolytic oscillations in individual isolated yeast...
Snapshots: No snapshots
Submitter: Katy Wolstencroft
Biological problem addressed: Model Analysis Type
Investigation: Yeast Glycolytic Oscillations
Organisms: No organisms
Models: Sustained glycolytic oscillations in individual..., Sustained glycolytic oscillations in individual..., Sustained glycolytic oscillations in individual..., Sustained glycolytic oscillations in individual...
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Abstract (Expand)
Authors: , David D van Niekerk, Bob Kooi, Johann M Rohwer,
Date Published: 21st Jun 2012
Publication Type: Not specified
PubMed ID: 22712534
Citation:
Abstract (Expand)
Authors: , David D van Niekerk,
Date Published: 13th Jun 2012
Publication Type: Not specified
PubMed ID: 22686585
Citation:
Abstract (Expand)
Authors: Anna-Karin Gustavsson, David D van Niekerk, Caroline B Adiels, , Mattias Goksör,
Date Published: 23rd May 2012
Publication Type: Not specified
PubMed ID: 22607453
Citation: