Sustained glycolytic oscillations in individual isolated yeast cells - I
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Using optical tweezers to position yeast cells in a microfluidic chamber, we were able to observe sustained oscillations in individual isolated cells. Using a detailed kinetic model for the cellular reactions, we simulated the heterogeneity in the response of the individual cells, assuming small differences in a single internal parameter. By operating at two different flow rates per experiment, we observe four of categories of cell behaviour. The present model (gustavsson1) predicts the limit cycles observed in 16.7% of the cell population at both flow rates.


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  • gustavsson1.dat (uuencoded file - 11.7 KB) Download

Organism: Saccharomyces cerevisiae

Model type: Ordinary differential equations (ODE)

Model format: Not specified

Execution or visualisation environment: JWS Online

Model image: No image specified

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David D van Niekerk

Views: 3037   Downloads: 157

Created: 23rd Jul 2012 at 23:39

Last updated: 23rd Jul 2012 at 01:53

Last used: 21st Oct 2019 at 14:23

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