Renz2020 - GEM of Human alveolar macrophage with SARS-CoV-2
Version 1

The novel coronavirus (SARS-CoV-2) currently spreads worldwide, causing the disease COVID-19. The number of infections increases daily, without any approved antiviral therapy. The recently released viral nucleotide sequence enables the identification of therapeutic targets, e.g., by analyzing integrated human-virus metabolic models. Investigations of changed metabolic processes after virus infections and the effect of knock-outs on the host and the virus can reveal new potential targets. Results: We generated an integrated host-virus genome-scale metabolic model of human alveolar macrophages and SARS-CoV-2. Analyses of stoichiometric and metabolic changes between uninfected and infected host cells using flux balance analysis (FBA) highlighted the different requirements of host and virus. Conclusion: Consequently, alterations in the metabolism can have different effects on host and virus, leading to potential antiviral targets. One of these potential targets is guanylate kinase (GK1). In FBA analyses, the knock-out of the guanylate kinase decreased the growth of the virus to zero, while not affecting the host. As GK1 inhibitors are described in the literature, its potential therapeutic effect for SARS-CoV-2 infections needs to be verified in in-vitro experiments.

Link: https://csbnc.informatik.uni-tuebingen.de/s/tbWGQq8iwSfHLCR Biomodels DB: https://www.ebi.ac.uk/biomodels/MODEL2003020001

SEEK ID: https://fairdomhub.org/models/699?version=1

1 item is associated with this Model:
  • iAB_AMO1410_SARS-CoV-2.xml (XML document - 7.57 MB) Download

Organism: Severe acute respiratory syndrome coronavirus 2

Model type: Not specified

Model format: SBML

Execution or visualisation environment: Not specified

Model image: No image specified

help Creators and Submitter
Activity

Views: 1812   Downloads: 112

Created: 3rd Apr 2020 at 17:13

Last updated: 26th May 2020 at 10:21

help Tags

This item has not yet been tagged.

help Attributions

None

Version History

Version 1 (earliest) Created 3rd Apr 2020 at 17:13 by Martin Golebiewski

No revision comments

Powered by
(v.1.14.2)
Copyright © 2008 - 2023 The University of Manchester and HITS gGmbH