Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range
SEEK ID: https://fairdomhub.org/investigations/82
Projects: Molecular Systems Biology
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Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications, SCyCode The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers, Project Coordination, WP 3: Drug release kinetics study, Glucose metabolism in cancer cell lines
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, University of Manchester - Department of Computer Science, Stellenbosch University
This programme is used to store published data files that are not available in other FAIRDOM projects. We specifically store information for journals that we collaborate with for technical curation of mathematical models. These files are used in COMBINE archives to reproduce journal figures.
Projects: Molecular Systems Biology
Web page: Not specified
The Molecular Systems Biology project holds information for reproducing simulation figures in the journal. This can include experimental data files, model files and manuscript information.
Programme: Journals
Public web page: http://msb.embopress.org
Organisms: Not specified
For all experiments, primary CFU-E cells were starved and stimulated with 5 U/ml Epo. At the indicated time points, samples were subjected to quantitative immunoblotting. Experimental data (black circles) with estimated standard errors and trajectories of the best fit (solid lines) are represented. Mass spectrometry data represent replicates of four independent experiments.
Submitter: Dawie van Niekerk
Investigation: Bachmann et al (2011) Molecular Systems Biology...
Assays: Model for JAK2/STAT5 signaling, Source data for Figure 3A: Experimental quantitative immunoblotting data.
Snapshots: No snapshots
Submitter: Dawie van Niekerk
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Bachmann et al (2011) Molecular Systems Biology...
Organisms: No organisms
SOPs: No SOPs
Data files: Source data for Figure 3A: Experimental quantit...
Snapshots: No snapshots
SED-ML simulation: https://jjj.bio.vu.nl/models/experiments/bachmann2011/simulate
Submitter: Dawie van Niekerk
Biological problem addressed: Model Analysis Type
Investigation: Bachmann et al (2011) Molecular Systems Biology...
Organisms: No organisms
Models: JAK2/STAT5 model
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
See 'Figure 3 legend' and 'Materials and methods - Time course experiments, cell lysis and quantitative immunoblotting' for details.
Creators: Dawie van Niekerk, Jacky Snoep
Submitter: Dawie van Niekerk
Creators: Dawie van Niekerk, Jacky Snoep
Submitter: Dawie van Niekerk
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: JWS Online
Organism: Not specified
Investigations: Bachmann et al (2011) Molecular Systems Biology...
Studies: Figure 3A: Model calibration with experimental ...
Assays: Model for JAK2/STAT5 signaling
Abstract (Expand)
Authors: J. Bachmann, A. Raue, M. Schilling, M. E. Bohm, C. Kreutz, D. Kaschek, H. Busch, N. Gretz, W. D. Lehmann, J. Timmer, U. Klingmuller
Date Published: 2011
Publication Type: Not specified
DOI: 10.1038/msb.2011.50
Citation: Molecular Systems Biology 7(1) : 516