cy3sabiork-SupplementaryFile-S2 Version 1
Supplementary File S2: Kinetic entries for human galactose metabolism. SBML for query: http://sabiork.h-its.org/sabioRestWebServices/searchKineticLaws/sbml?q=Pathway:%22galactose%20metabolism%22%20AND%20Organism:%22homo%20sapiens%22
SEEK ID: https://fairdomhub.org/data_files/1428?version=1
Filename:
cy3sabiork-SupplementaryFile-S2.xml
Format: XML document
Size: 495 KB
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<p>This model has been created with the help of the SABIO-RK Database (http://sabio.h-its.org/) (c) 2005-2016 HITS gGmbH http://www.h-its.org</p>
<br />
To cite SABIO-RK Database, please use "http://www.ncbi.nlm.nih.gov/pubmed/22102587"
<br />
SABIO-RK - database for biochemical reaction kinetics. Wittig U, Kania R, Golebiewski M, Rey M, Shi L, Jong L, Algaa E, Weidemann A, Sauer-Danzwith H, Mir S, Krebs O, Bittkowski M, Wetsch E,
Rojas I, Mueller W. Nucleic Acids Res. 2012;40(Database issue)790-6</body>
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</bvar>
<bvar>
<ci>kcat_KmA</ci>
</bvar>
<bvar>
<ci>KmB</ci>
</bvar>
<bvar>
<ci>kcat</ci>
</bvar>
<bvar>
<ci>KmA</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>E</ci>
</bvar>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<ci>E</ci>
<ci>kcat</ci>
</apply>
<ci>B</ci>
</apply>
<apply>
<plus />
<ci>KmB</ci>
<ci>B</ci>
</apply>
</apply>
<ci>A</ci>
</apply>
<apply>
<plus />
<ci>KmA</ci>
<ci>A</ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_14788" sboTerm="SBO:0000433">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>KmB</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>E</ci>
</bvar>
<bvar>
<ci>kcat</ci>
</bvar>
<bvar>
<ci>kcat_KmA</ci>
</bvar>
<bvar>
<ci>KmA</ci>
</bvar>
<bvar>
<ci>kcat_KmB</ci>
</bvar>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<ci>E</ci>
<ci>kcat</ci>
</apply>
<ci>B</ci>
</apply>
<apply>
<plus />
<ci>KmB</ci>
<ci>B</ci>
</apply>
</apply>
<ci>A</ci>
</apply>
<apply>
<plus />
<ci>KmA</ci>
<ci>A</ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_14791" sboTerm="SBO:0000433">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>KmB</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>kcat_KmA</ci>
</bvar>
<bvar>
<ci>kcat_KmB</ci>
</bvar>
<bvar>
<ci>KmA</ci>
</bvar>
<bvar>
<ci>kcat</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>E</ci>
</bvar>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<ci>E</ci>
<ci>kcat</ci>
</apply>
<ci>B</ci>
</apply>
<apply>
<plus />
<ci>KmB</ci>
<ci>B</ci>
</apply>
</apply>
<ci>A</ci>
</apply>
<apply>
<plus />
<ci>KmA</ci>
<ci>A</ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_14789" sboTerm="SBO:0000433">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>KmB</ci>
</bvar>
<bvar>
<ci>KmA</ci>
</bvar>
<bvar>
<ci>E</ci>
</bvar>
<bvar>
<ci>kcat_KmB</ci>
</bvar>
<bvar>
<ci>kcat_KmA</ci>
</bvar>
<bvar>
<ci>kcat</ci>
</bvar>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<ci>E</ci>
<ci>kcat</ci>
</apply>
<ci>B</ci>
</apply>
<apply>
<plus />
<ci>KmB</ci>
<ci>B</ci>
</apply>
</apply>
<ci>A</ci>
</apply>
<apply>
<plus />
<ci>KmA</ci>
<ci>A</ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_14790" sboTerm="SBO:0000433">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>KmA</ci>
</bvar>
<bvar>
<ci>kcat_KmA</ci>
</bvar>
<bvar>
<ci>E</ci>
</bvar>
<bvar>
<ci>kcat</ci>
</bvar>
<bvar>
<ci>kcat_KmB</ci>
</bvar>
<bvar>
<ci>KmB</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<ci>E</ci>
<ci>kcat</ci>
</apply>
<ci>B</ci>
</apply>
<apply>
<plus />
<ci>KmB</ci>
<ci>B</ci>
</apply>
</apply>
<ci>A</ci>
</apply>
<apply>
<plus />
<ci>KmA</ci>
<ci>A</ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_14792" sboTerm="SBO:0000029">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>E</ci>
</bvar>
<bvar>
<ci>kcat</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>kcat_Km</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<ci>E</ci>
<ci>kcat</ci>
</apply>
<ci>A</ci>
</apply>
<apply>
<plus />
<ci>Km</ci>
<ci>A</ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33648" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>kcat_Km</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Activity</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33649" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Activity</ci>
</bvar>
<bvar>
<ci>kcat_Km</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33647" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Activity</ci>
</bvar>
<bvar>
<ci>kcat_Km</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33642" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Activity</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33643" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Activity</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33646" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>Activity</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33645" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>Activity</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33644" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Activity</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33652" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>kcat_Km</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>Activity</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33651" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Activity</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>kcat_Km</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33653" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Activity</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>kcat_Km</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_33650" sboTerm="SBO:0000436">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>kcat_Km</ci>
</bvar>
<bvar>
<ci>B</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Activity</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_50494" sboTerm="SBO:0000169">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Ki</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_50491" sboTerm="SBO:0000029">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Vmax</ci>
</bvar>
<bvar>
<ci>E</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>S</ci>
</bvar>
<apply>
<divide />
<apply>
<times />
<ci>Vmax</ci>
<ci>S</ci>
</apply>
<apply>
<plus />
<ci>S</ci>
<ci>Km</ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_50493" sboTerm="SBO:0000029">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>S</ci>
</bvar>
<bvar>
<ci>Vmax</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<apply>
<divide />
<apply>
<times />
<ci>Vmax</ci>
<ci>S</ci>
</apply>
<apply>
<plus />
<ci>S</ci>
<ci>Km</ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_50492" sboTerm="SBO:0000029">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>S</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>Vmax</ci>
</bvar>
<apply>
<divide />
<apply>
<times />
<ci>Vmax</ci>
<ci>S</ci>
</apply>
<apply>
<plus />
<ci>S</ci>
<ci>Km</ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48027">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Vmax</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_49017" sboTerm="SBO:0000260">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>C</ci>
</bvar>
<bvar>
<ci>Ki</ci>
</bvar>
<bvar>
<ci>I</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_49018" sboTerm="SBO:0000260">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>I</ci>
</bvar>
<bvar>
<ci>Ki</ci>
</bvar>
<bvar>
<ci>C</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_49019" sboTerm="SBO:0000260">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>I</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Ki</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_49013" sboTerm="SBO:0000260">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>I</ci>
</bvar>
<bvar>
<ci>Ki</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_49014" sboTerm="SBO:0000260">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Ki</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>I</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48034">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48036">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48033" sboTerm="SBO:0000029">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Vmax</ci>
</bvar>
<apply>
<divide />
<apply>
<times />
<ci>Vmax</ci>
<ci>A</ci>
</apply>
<apply>
<plus />
<ci>Km</ci>
<ci>A</ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48035">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48994">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>C</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48993">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_49004">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_49063">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>S</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_49064">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>S</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48020">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Vmax</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48427">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>Vmax</ci>
</bvar>
<bvar>
<ci>Spec_Act</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48426">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Spec_Act</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Vmax</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48425">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>Spec_Act</ci>
</bvar>
<bvar>
<ci>Vmax</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48424">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>Vmax</ci>
</bvar>
<bvar>
<ci>Km</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>Spec_Act</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48429" sboTerm="SBO:0000169">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>IC_50</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48430" sboTerm="SBO:0000169">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>IC_50</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48431" sboTerm="SBO:0000169">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>IC_50</ci>
</bvar>
<bvar>
<ci>A</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48428" sboTerm="SBO:0000169">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci>A</ci>
</bvar>
<bvar>
<ci>IC_50</ci>
</bvar>
<notanumber />
</lambda>
</math>
</functionDefinition>
<functionDefinition id="KL_48996">
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</sbrk:temperature>
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</sbrk:pH>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<ci>KL_45402</ci>
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</apply>
</math>
<listOfLocalParameters>
<localParameter id="REAC_16_kcat" name="kcat" sboTerm="SBO:0000025" value="15" />
<localParameter id="REAC_16_kcat_Km_SPC_3919_Cell" name="kcat_Km_UDPgalactose" sboTerm="SBO:0000302" value="150000" />
<localParameter id="REAC_16_Km_SPC_3919_Cell" name="Km_UDPgalactose" sboTerm="SBO:0000027" units="M" value="9.9E-5" />
</listOfLocalParameters>
</kineticLaw>
</reaction>
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</annotation>
<listOfReactants>
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</sbrk:temperature>
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</sbrk:pH>
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</annotation>
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<apply>
<ci>KL_45401</ci>
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</apply>
</math>
<listOfLocalParameters>
<localParameter id="REAC_17_kcat" name="kcat" sboTerm="SBO:0000025" value="30" />
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<localParameter id="REAC_17_kcat_Km_SPC_3919_Cell" name="kcat_Km_UDPgalactose" sboTerm="SBO:0000302" value="390000" />
</listOfLocalParameters>
</kineticLaw>
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</annotation>
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<sbrk:kineticLawID>45400</sbrk:kineticLawID>
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</sbrk:temperature>
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</sbrk:pH>
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</rdf:RDF>
</annotation>
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<apply>
<ci>KL_45400</ci>
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</apply>
</math>
<listOfLocalParameters>
<localParameter id="REAC_18_kcat" name="kcat" sboTerm="SBO:0000025" value="5.8" />
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<localParameter id="REAC_18_Km_SPC_3919_Cell" name="Km_UDPgalactose" sboTerm="SBO:0000027" units="M" value="3.5E-5" />
</listOfLocalParameters>
</kineticLaw>
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</annotation>
<listOfReactants>
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</sbrk:temperature>
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</sbrk:pH>
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</annotation>
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<apply>
<ci>KL_46263</ci>
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</apply>
</math>
<listOfLocalParameters>
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</listOfLocalParameters>
</kineticLaw>
</reaction>
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</annotation>
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</sbrk:temperature>
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</sbrk:pH>
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</annotation>
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<apply>
<ci>KL_46264</ci>
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</apply>
</math>
<listOfLocalParameters>
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</listOfLocalParameters>
</kineticLaw>
</reaction>
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</annotation>
<listOfReactants>
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</sbrk:temperature>
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</sbrk:pH>
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</sbrk:experimentalConditions>
</sbrk:sabiork>
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</annotation>
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<apply>
<ci>KL_46260</ci>
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</apply>
</math>
<listOfLocalParameters>
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</listOfLocalParameters>
</kineticLaw>
</reaction>
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</math>
<listOfLocalParameters>
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</listOfLocalParameters>
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</math>
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</math>
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<sbrk:sabiork xmlns:sbrk="http://sabiork.h-its.org">
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<sbrk:pH>
<sbrk:startValuepH>8.0</sbrk:startValuepH>
</sbrk:pH>
<sbrk:temperature>
<sbrk:startValueTemperature>37.0</sbrk:startValueTemperature>
<sbrk:temperatureUnit>°C</sbrk:temperatureUnit>
</sbrk:temperature>
<sbrk:buffer>20 mM Hepes, 150 mM NaCl, 5 mM MgCl2, 1 mM KCl, 10% (v/v) glycerrol, 1 mM NADH, 1 mM dithiothreitol, 400 µM phosphoenolpyrovate, 7.5 U pyrovate kinase, 10 U lactate
dehydrogenase</sbrk:buffer>
</sbrk:experimentalConditions>
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</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<ci>KL_14791</ci>
<ci>REAC_33_KmB_SPC_34_cytosol</ci>
<ci>SPC_34_cytosol</ci>
<ci>REAC_33_kcat_KmA_SPC_1661_cytosol</ci>
<ci>REAC_33_kcat_KmB_SPC_34_cytosol</ci>
<ci>REAC_33_KmA_SPC_1661_cytosol</ci>
<ci>REAC_33_kcat</ci>
<ci>SPC_1661_cytosol</ci>
<ci>ENZ_77018_cytosol</ci>
</apply>
</math>
<listOfLocalParameters>
<localParameter id="REAC_33_KmB_SPC_34_cytosol" name="KmB_ATP" sboTerm="SBO:0000027" units="M" value="3.9E-5" />
<localParameter id="REAC_33_kcat_KmA_SPC_1661_cytosol" name="kcat_KmA_DGalactose" sboTerm="SBO:0000302" value="1100" />
<localParameter id="REAC_33_kcat_KmB_SPC_34_cytosol" name="kcat_KmB_ATP" sboTerm="SBO:0000302" value="46000" />
<localParameter id="REAC_33_KmA_SPC_1661_cytosol" name="KmA_DGalactose" sboTerm="SBO:0000027" units="M" value="0.0017" />
<localParameter id="REAC_33_kcat" name="kcat" sboTerm="SBO:0000025" value="1.8" />
</listOfLocalParameters>
</kineticLaw>
</reaction>
<reaction fast="false" id="REAC_34" metaid="META_REAC_34" reversible="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#META_REAC_34">
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</rdf:Bag>
</bqbiol:isVersionOf>
<bqbiol:is>
<rdf:Bag>
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</rdf:Bag>
</bqbiol:is>
<bqbiol:hasTaxon>
<rdf:Bag>
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</rdf:Bag>
</bqbiol:hasTaxon>
<bqbiol:is>
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</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference constant="true" sboTerm="SBO:0000015" species="SPC_34_cytosol" stoichiometry="1" />
<speciesReference constant="true" sboTerm="SBO:0000015" species="SPC_1661_cytosol" stoichiometry="1" />
</listOfReactants>
<listOfProducts>
<speciesReference constant="true" sboTerm="SBO:0000011" species="SPC_35_cytosol" stoichiometry="1" />
<speciesReference constant="true" sboTerm="SBO:0000011" species="SPC_1381_cytosol" stoichiometry="1" />
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference sboTerm="SBO:0000460" species="ENZ_77008_cytosol" />
</listOfModifiers>
<kineticLaw metaid="META_KL_14789" sboTerm="SBO:0000433">
<annotation>
<sbrk:sabiork xmlns:sbrk="http://sabiork.h-its.org">
<sbrk:kineticLawID>14789</sbrk:kineticLawID>
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<sbrk:pH>
<sbrk:startValuepH>8.0</sbrk:startValuepH>
</sbrk:pH>
<sbrk:temperature>
<sbrk:startValueTemperature>37.0</sbrk:startValueTemperature>
<sbrk:temperatureUnit>°C</sbrk:temperatureUnit>
</sbrk:temperature>
<sbrk:buffer>20 mM Hepes, 150 mM NaCl, 5 mM MgCl2, 1 mM KCl, 10% (v/v) glycerrol, 1 mM NADH, 1 mM dithiothreitol, 400 µM phosphoenolpyrovate, 7.5 U pyrovate kinase, 10 U lactate
dehydrogenase</sbrk:buffer>
</sbrk:experimentalConditions>
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</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<ci>KL_14789</ci>
<ci>SPC_1661_cytosol</ci>
<ci>SPC_34_cytosol</ci>
<ci>REAC_34_KmB_SPC_34_cytosol</ci>
<ci>REAC_34_KmA_SPC_1661_cytosol</ci>
<ci>ENZ_77008_cytosol</ci>
<ci>REAC_34_kcat_KmB_SPC_34_cytosol</ci>
<ci>REAC_34_kcat_KmA_SPC_1661_cytosol</ci>
<ci>REAC_34_kcat</ci>
</apply>
</math>
<listOfLocalParameters>
<localParameter id="REAC_34_KmB_SPC_34_cytosol" name="KmB_ATP" sboTerm="SBO:0000027" units="M" value="5E-6" />
<localParameter id="REAC_34_KmA_SPC_1661_cytosol" name="KmA_DGalactose" sboTerm="SBO:0000027" units="M" value="0.0011" />
<localParameter id="REAC_34_kcat_KmB_SPC_34_cytosol" name="kcat_KmB_ATP" sboTerm="SBO:0000302" value="87000" />
<localParameter id="REAC_34_kcat_KmA_SPC_1661_cytosol" name="kcat_KmA_DGalactose" sboTerm="SBO:0000302" value="400" />
<localParameter id="REAC_34_kcat" name="kcat" sboTerm="SBO:0000025" value="0.4" />
</listOfLocalParameters>
</kineticLaw>
</reaction>
<reaction fast="false" id="REAC_35" metaid="META_REAC_35" reversible="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#META_REAC_35">
<bqbiol:isVersionOf>
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<rdf:li rdf:resource="http://identifiers.org/ec-code/2.7.1.6" />
</rdf:Bag>
</bqbiol:isVersionOf>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/kegg.reaction/R01092" />
</rdf:Bag>
</bqbiol:is>
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<rdf:Bag>
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</rdf:Bag>
</bqbiol:hasTaxon>
<bqbiol:is>
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<rdf:li rdf:resource="http://identifiers.org/sabiork.reaction/1354" />
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference constant="true" sboTerm="SBO:0000015" species="SPC_34_cytosol" stoichiometry="1" />
<speciesReference constant="true" sboTerm="SBO:0000015" species="SPC_1661_cytosol" stoichiometry="1" />
</listOfReactants>
<listOfProducts>
<speciesReference constant="true" sboTerm="SBO:0000011" species="SPC_35_cytosol" stoichiometry="1" />
<speciesReference constant="true" sboTerm="SBO:0000011" species="SPC_1381_cytosol" stoichiometry="1" />
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference sboTerm="SBO:0000460" species="ENZ_77013_cytosol" />
</listOfModifiers>
<kineticLaw metaid="META_KL_14790" sboTerm="SBO:0000433">
<annotation>
<sbrk:sabiork xmlns:sbrk="http://sabiork.h-its.org">
<sbrk:kineticLawID>14790</sbrk:kineticLawID>
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<sbrk:pH>
<sbrk:startValuepH>8.0</sbrk:startValuepH>
</sbrk:pH>
<sbrk:temperature>
<sbrk:startValueTemperature>37.0</sbrk:startValueTemperature>
<sbrk:temperatureUnit>°C</sbrk:temperatureUnit>
</sbrk:temperature>
<sbrk:buffer>20 mM Hepes, 150 mM NaCl, 5 mM MgCl2, 1 mM KCl, 10% (v/v) glycerrol, 1 mM NADH, 1 mM dithiothreitol, 400 µM phosphoenolpyrovate, 7.5 U pyrovate kinase, 10 U lactate
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</sbrk:experimentalConditions>
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<rdf:Bag>
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</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<ci>KL_14790</ci>
<ci>REAC_35_KmA_SPC_1661_cytosol</ci>
<ci>REAC_35_kcat_KmA_SPC_1661_cytosol</ci>
<ci>ENZ_77013_cytosol</ci>
<ci>REAC_35_kcat</ci>
<ci>REAC_35_kcat_KmB_SPC_34_cytosol</ci>
<ci>REAC_35_KmB_SPC_34_cytosol</ci>
<ci>SPC_1661_cytosol</ci>
<ci>SPC_34_cytosol</ci>
</apply>
</math>
<listOfLocalParameters>
<localParameter id="REAC_35_KmA_SPC_1661_cytosol" name="KmA_DGalactose" sboTerm="SBO:0000027" units="M" value="0.013" />
<localParameter id="REAC_35_kcat_KmA_SPC_1661_cytosol" name="kcat_KmA_DGalactose" sboTerm="SBO:0000302" value="85" />
<localParameter id="REAC_35_kcat" name="kcat" sboTerm="SBO:0000025" value="1.1" />
<localParameter id="REAC_35_kcat_KmB_SPC_34_cytosol" name="kcat_KmB_ATP" sboTerm="SBO:0000302" value="12000" />
<localParameter id="REAC_35_KmB_SPC_34_cytosol" name="KmB_ATP" sboTerm="SBO:0000027" units="M" value="8.9E-5" />
</listOfLocalParameters>
</kineticLaw>
</reaction>
<reaction fast="false" id="REAC_36" metaid="META_REAC_36" reversible="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#META_REAC_36">
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</rdf:Bag>
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</rdf:Bag>
</bqbiol:hasTaxon>
<bqbiol:is>
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</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference constant="true" sboTerm="SBO:0000015" species="SPC_1661_cytosol" stoichiometry="1" />
<speciesReference constant="true" sboTerm="SBO:0000015" species="SPC_34_cytosol" stoichiometry="1" />
</listOfReactants>
<listOfProducts>
<speciesReference constant="true" sboTerm="SBO:0000011" species="SPC_35_cytosol" stoichiometry="1" />
<speciesReference constant="true" sboTerm="SBO:0000011" species="SPC_1381_cytosol" stoichiometry="1" />
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference sboTerm="SBO:0000460" species="ENZ_77023_cytosol" />
</listOfModifiers>
<kineticLaw metaid="META_KL_14792" sboTerm="SBO:0000029">
<annotation>
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<sbrk:startValuepH>8.0</sbrk:startValuepH>
</sbrk:pH>
<sbrk:temperature>
<sbrk:startValueTemperature>37.0</sbrk:startValueTemperature>
<sbrk:temperatureUnit>°C</sbrk:temperatureUnit>
</sbrk:temperature>
<sbrk:buffer>20 mM Hepes, 150 mM NaCl, 5 mM MgCl2, 1 mM KCl, 10% (v/v) glycerrol, 1 mM NADH, 1 mM dithiothreitol, 400 µM phosphoenolpyrovate, 7.5 U pyrovate kinase, 10 U lactate
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</sbrk:experimentalConditions>
</sbrk:sabiork>
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</rdf:Bag>
</bqbiol:isDescribedBy>
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<rdf:Bag>
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</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<ci>KL_14792</ci>
<ci>ENZ_77023_cytosol</ci>
<ci>REAC_36_kcat</ci>
<ci>SPC_34_cytosol</ci>
<ci>REAC_36_kcat_Km_SPC_34_cytosol</ci>
<ci>REAC_36_Km_SPC_34_cytosol</ci>
</apply>
</math>
<listOfLocalParameters>
<localParameter id="REAC_36_kcat" name="kcat" sboTerm="SBO:0000025" value="8.7" />
<localParameter id="REAC_36_kcat_Km_SPC_34_cytosol" name="kcat_Km_ATP" sboTerm="SBO:0000302" value="260000" />
<localParameter id="REAC_36_Km_SPC_34_cytosol" name="Km_ATP" sboTerm="SBO:0000027" units="M" value="3.4E-5" />
</listOfLocalParameters>
</kineticLaw>
</reaction>
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<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#META_REAC_37">
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</rdf:Bag>
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<bqbiol:hasTaxon>
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</rdf:Bag>
</bqbiol:hasTaxon>
<bqbiol:is>
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</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference constant="true" sboTerm="SBO:0000015" species="SPC_3918_Cell" stoichiometry="1" />
<speciesReference constant="true" sboTerm="SBO:0000015" species="SPC_1381_Cell" stoichiometry="1" />
</listOfReactants>
<listOfProducts>
<speciesReference constant="true" sboTerm="SBO:0000011" species="SPC_1450_Cell" stoichiometry="1" />
<speciesReference constant="true" sboTerm="SBO:0000011" species="SPC_3919_Cell" stoichiometry="1" />
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference sboTerm="SBO:0000460" species="ENZ_190152_Cell" />
</listOfModifiers>
<kineticLaw metaid="META_KL_33648" sboTerm="SBO:0000436">
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<sbrk:sabiork xmlns:sbrk="http://sabiork.h-its.org">
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<sbrk:startValuepH>8.7</sbrk:startValuepH>
</sbrk:pH>
<sbrk:temperature>
<sbrk:startValueTemperature>37.0</sbrk:startValueTemperature>
<sbrk:temperatureUnit>°C</sbrk:temperatureUnit>
</sbrk:temperature>
<sbrk:buffer>0.1 M GLY-GLY, 5 mM Dithiothreitol, 5 µM Glucose 1,6-diphosphate, 5 µM MgCl2, 0.8 mM NADP, 0.15 µg/ml Glucose-6-phosphate dehydrogenase, 0.25 µg/ml
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</sbrk:experimentalConditions>
</sbrk:sabiork>
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</rdf:RDF>
</annotation>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<ci>KL_33648</ci>
<ci>SPC_3918_Cell</ci>
<ci>REAC_37_Km_SPC_1381_Cell</ci>
<ci>REAC_37_kcat_Km_SPC_1381_Cell</ci>
<ci>SPC_1381_Cell</ci>
<ci>REAC_37_Activity</ci>
</apply>
</math>
<listOfLocalParameters>
<localParameter id="REAC_37_Km_SPC_1381_Cell" name="Km_alphaDGalactose_1phosphate" sboTerm="SBO:0000027" units="M" value="9E-5" />
<localParameter id="REAC_37_kcat_Km_SPC_1381_Cell" name="kcat_Km_alphaDGalactose_1phosphate" sboTerm="SBO:0000302" value="16000" />
<localParameter id="REAC_37_Activity" name="Activity" sboTerm="SBO:0000558" value="2.7E-5" />
</listOfLocalParameters>
</kineticLaw>
</reaction>
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</rdf:Bag>
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</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfReactants>
<speciesReference constant="true" sboTerm="SBO:0000015" species="SPC_3918_Cell" stoichiometry="1" />
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</listOfReactants>
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<ci>KL_49160</ci>
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<localParameter id="REAC_87_Km_SPC_28371_Cell" name="Km_4MethylumbelliferylalphaDgalactoside" sboTerm="SBO:0000027" units="M" value="0.004" />
</listOfLocalParameters>
</kineticLaw>
</reaction>
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</model>
</sbml>
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Created: 18th Jul 2016 at 16:42
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Version 1 (earliest) Created 18th Jul 2016 at 16:42 by Matthias König
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https://orcid.org/0000-0003-1725-179X
Projects: Kinetics on the move - Workshop 2016, Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), FAIRDOM user meeting, COMBINE Multicellular Modelling, FAIRDOM & LiSyM & de.NBI Data Structuring Training
Institutions: Charité University Medicine Berlin, Humboldt-Universität zu Berlin, Humboldt University Berlin
https://orcid.org/0000-0003-1725-179X
We are investigating liver metabolism and function with the help of computational models and methods.
Group Leader Dr. Matthias König
Institute for Theoretical Biology Humboldt-University Berlin Philippstraße 13, 10115 Berlin, Germany phone +49 30 2093-98435 koenigmx@hu-berlin.de https://www.livermetabolism.com
The König group works on computational modeling, data science, data management, bioinformatics methods and machine learning on ...
Advanced Programmes list for this Data file with search and filtering
LiSyM (Liver Systems Medicine) represents a research network of German centers and institutions, brought together by a 20 Million Euro funding program of the German Government, in which mathematicians, modelers, pharmacologists, molecular biologists and clinical scientists work together to develop a Systems Medicine approach to study early and advanced liver disease. The aim of this unique research program is to acquire and use new experimental data and data from existing data bases to build ...
Projects: Early Metabolic Injury (LiSyM-EMI - Pillar I), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), LiSyM Core Infrastructure and Management (LiSyM-PD), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), FAIRDOM & LiSyM & de.NBI Data Structuring Training, New LiSyM project
Web page: http://www.lisym.org
Advanced Projects list for this Data file with search and filtering
We will contribute to the LiSyM Research Network an open source, freely available and reproducible multiscale model of the human liver from single cell metabolism to whole liver function. The model will be available in existing standards of systems biology, provide standardized interfaces for data integration and be fully annotated to available biological, medical and computational ontologies. All data, models and source code will be shared within the LiSyM Research Network and made available to ...
Programme: LiSyM - Systems Medicine of the Liver
Public web page: https://livermetabolism.com
