Quantitative analysis of drug effects at the whole-body level: a case study for glucose metabolism in malaria patients

Abstract:

We propose a hierarchical modelling approach to construct models for disease states at the whole-body level. Such models can simulate effects of drug-induced inhibition of reaction steps on the whole-body physiology. We illustrate the approach for glucose metabolism in malaria patients, by merging two detailed kinetic models for glucose metabolism in the parasite Plasmodium falciparum and the human red blood cell with a coarse-grained model for whole-body glucose metabolism. In addition we use a genome-scale metabolic model for the parasite to predict amino acid production profiles by the malaria parasite that can be used as a complex biomarker.

SEEK ID: https://fairdomhub.org/publications/269

DOI: 10.1042/BST20150145

Projects: Whole body modelling of glucose metabolism in malaria patients

Publication type: Not specified

Journal: Biochemical Society Transactions

Citation: Biochemical Society Transactions 43(6) : 1157

Date Published: 27th Nov 2015

Registered Mode: Not specified

Authors: J. L. Snoep, K. Green, J. Eicher, D. C. Palm, G. Penkler, F. du Toit, N. Walters, R. Burger, H. V. Westerhoff, D. D. van Niekerk

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Citation
Snoep, J. L., Green, K., Eicher, J., Palm, D. C., Penkler, G., du Toit, F., Walters, N., Burger, R., Westerhoff, H. V., & van Niekerk, D. D. (2015). Quantitative analysis of drug effects at the whole-body level: a case study for glucose metabolism in malaria patients. In Biochemical Society Transactions (Vol. 43, Issue 6, pp. 1157–1163). Portland Press Ltd. https://doi.org/10.1042/bst20150145
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Created: 30th Aug 2016 at 15:09

Last updated: 19th Sep 2016 at 15:35

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