Figure 4B: A minimal mathematical model, containing an incoherent feedforward loop modulated by an oscillatory signal, reproduces the experimental observations.
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Numerical simulations of the wild-type network show double peaks of expression (red line), and numerical simulations of a SigC knock-out model (in which the terms representing the regulation of PsbAI by SigC are set to zero) show only single-peaked oscillations (blue line)..
SED-ML simulation https://jjj.bio.vu.nl/models/experiments/martins2016_fig4b/simulate
SEEK ID: https://fairdomhub.org/studies/381
Martins et al (2016) Molecular Systems Biology
Projects: Molecular Systems Biology
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Created: 30th Jul 2018 at 14:02
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Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications, SCyCode The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers, Project Coordination, WP 3: Drug release kinetics study, Glucose metabolism in cancer cell lines
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, University of Manchester - Department of Computer Science, Stellenbosch University
This programme is used to store published data files that are not available in other FAIRDOM projects. We specifically store information for journals that we collaborate with for technical curation of mathematical models. These files are used in COMBINE archives to reproduce journal figures.
Projects: Molecular Systems Biology
Web page: Not specified
The Molecular Systems Biology project holds information for reproducing simulation figures in the journal. This can include experimental data files, model files and manuscript information.
Programme: Journals
Public web page: http://msb.embopress.org
Frequency doubling in the cyanobacterial circadian clock
Submitter: Jacky Snoep
Studies: Figure 4B: A minimal mathematical model, containing an incoherent feedfo..., Figure 6C and D: The clock-sigC circuit represents a general mechanism t...
Assays: Frequency doubling in the cyanobacterial circadian clock, Frequency doubling in the cyanobacterial circadian clock
Submitter: Jacky Snoep
Biological problem addressed: Model Analysis Type
Investigation: Martins et al (2016) Molecular Systems Biology
Creator: Jacky Snoep
Submitter: Jacky Snoep
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: JWS Online
