Interchangeable modules in bacterial thiol-disulfide exchange pathways

Abstract:

Thiol-disulfide oxidoreductases (TDORs) catalyze thiol-disulfide exchange reactions that are crucial for protein activity and stability. Specifically, they can function as thiol oxidases, disulfide reductases or disulfide isomerases. The generally established view is that particular TDORs act unidirectionally within a fixed cascade of specific, sequentially arranged reactions. However, recent studies on both Gram-negative and Gram-positive bacteria imply that this view needs to be expanded, at least for thiol-disulfide exchanges in proteins that are exported from the cytoplasm. Here, we present our opinion that various TDORs can function as interchangeable modules in different thiol-disulfide exchange pathways. Such TDOR modules, thus, fulfil important functions in generating the diversity in activity and specificity that is needed in productive extracytoplasmic thiol-disulfide exchange.

SEEK ID: https://fairdomhub.org/publications/58

PubMed ID: 19059781

Projects: BaCell-SysMO

Publication type: Not specified

Journal: Trends Microbiol.

Citation:

Date Published: 30th May 2008

Registered Mode: Not specified

Authors: Thijs R H M Kouwen,

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Created: 20th Aug 2010 at 13:52

Last updated: 8th Dec 2022 at 17:25

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