Insights into Streptococcus pyogenes pathogenesis from transcriptome studies


Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal mucosal membrane, up to severe systemic and invasive diseases and autoimmune sequelae. The capability of GAS to cause this wide variety of infections is due to the expression of a large set of virulence factors, their concerted transcriptional regulation, and bacterial adaptation mechanisms to various host niches, which we are now beginning to understand on a molecular level. The addition of -omics technologies for GAS pathogenesis investigation, on top of traditional molecular methods, led to fast progress in understanding GAS pathogenesis mechanisms. This article focuses on differential transcriptional analysis performed on the bacterial side as well as on the host cell side. The microarray studies discussed provide new insight into the following five topics: gene-expression patterns under infection-relevant conditions, gene-expression patterns in mutant strains compared with wild-type strains, emergence of exceptionally fit GAS clones, gene-expression patterns of eukaryotic target and immune cells in response to GAS infection, and mechanisms underlying shifts from a pharyngeal to invasive GAS lifestyle.


PubMed ID: 21133689

Projects: SysMO-LAB

Publication type: Not specified

Journal: Future Microbiol


Date Published: 8th Dec 2010

Registered Mode: Not specified

Authors: , Venelina Sugareva, Nadja Patenge,

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Views: 4752

Created: 25th Jan 2011 at 08:58

Last updated: 8th Dec 2022 at 17:26

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