Botond Cseke

"Systems Understanding of Microbial Oxygen responses" (SUMO) investigates how Escherichia coli senses oxygen, or the associated changes in oxidation/reduction balance, via the Fnr and ArcA proteins, how these systems interact with other regulatory systems, and how the redox response of an E. coli population is generated from the responses of single cells. There are five sub-projects to determine system properties and behaviour and three sub-projects to employ different and complementary modelling ...

Using TFinfer2 to analyse data from "Characterization of MG1655 and mutant strains under conditions of glucose excess and limitation"

Code for joint probabilistic inference of transcription factor behaviour and gene-transcription factor as well as metabolite-transcription factor interaction based on genome and metabolite data.

Summary 1.1 modifying TFinfer to model the TFs using ON/OFF switches (fast response model), 1.2 trying to infer metabolites effect using a joint gene-tf-metabolite model, 2 analysing aerbiosis data using a similar model, 3 clustering genes for extending the EC network to obtain better fits to the data (feedback loop).