Kinetic model of antibiotic-mediated inhibition of ribosomes Version 1
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Simulate Model on JWSSEEK ID: https://fairdomhub.org/models/279?version=1
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srimani1.xml (XML document - 8.82 KB)
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Model type: Ordinary differential equations (ODE)
Model format: SBML
Execution or visualisation environment: JWS Online
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Created: 26th Sep 2017 at 10:02
Last updated: 27th Sep 2017 at 10:30
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Version 1 (earliest) Created 26th Sep 2017 at 10:02 by Dawie van Niekerk
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Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications, SCyCode The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers, Project Coordination, WP 3: Drug release kinetics study, Glucose metabolism in cancer cell lines
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, University of Manchester - Department of Computer Science, Stellenbosch University
https://orcid.org/0000-0003-2633-0537
This programme is used to store published data files that are not available in other FAIRDOM projects. We specifically store information for journals that we collaborate with for technical curation of mathematical models. These files are used in COMBINE archives to reproduce journal figures.
Projects: Molecular Systems Biology
Web page: Not specified
The Molecular Systems Biology project holds information for reproducing simulation figures in the journal. This can include experimental data files, model files and manuscript information.
Programme: Journals
Public web page: http://msb.embopress.org
Drug detoxification dynamics explain the postantibiotic effect
After the removal of the extracellular antibiotic, efflux and inhibition dynamics combine to delay the synthesis of ribosomes in a concentration-dependent manner (panel ii). Colors indicate increasing antibiotic concentration, as shown in panel ii.
SED-ML simulation https://jjj.bio.vu.nl/models/experiments/srimani2017_fig2cii/simulate
Submitter: Dawie van Niekerk
Investigation: Srimani et al (2017) Molecular Systems Biology
Assays: Kinetic model of antibiotic-mediated inhibition of ribosomes
Submitter: Dawie van Niekerk
Biological problem addressed: Model Analysis Type
Investigation: Srimani et al (2017) Molecular Systems Biology
