Kinetic model of antibiotic-mediated inhibition of ribosomes
SEEK ID: https://fairdomhub.org/assays/567
Modelling Analysis
Projects: Molecular Systems Biology
Investigation: Srimani et al (2017) Molecular Systems Biology
Biological problem addressed: Model Analysis Type
Organisms: No organisms
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Created: 26th Sep 2017 at 11:59
Last updated: 8th Nov 2017 at 15:21
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orcid.org/0000-0003-2633-0537
Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, School of Computer Science, University of Manchester, Stellenbosch University
The Molecular Systems Biology project holds information for reproducing simulation figures in the journal. This can include experimental data files, model files and manuscript information.
Programme: Journals
Public web page: http://msb.embopress.org
Drug detoxification dynamics explain the postantibiotic effect
Snapshots: No snapshots
After the removal of the extracellular antibiotic, efflux and inhibition dynamics combine to delay the synthesis of ribosomes in a concentration-dependent manner (panel ii). Colors indicate increasing antibiotic concentration, as shown in panel ii.
SED-ML simulation
https://jjj.bio.vu.nl/models/experiments/srimani2017_fig2cii/simulate
Person responsible: Dawie Van Niekerk
Snapshots: No snapshots
Creators: Dawie Van Niekerk, Jacky Snoep
Contributor: Dawie Van Niekerk
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: JWS Online
