Kinetic model of antibiotic-mediated inhibition of ribosomes
SEEK ID: https://fairdomhub.org/assays/567
Modelling Analysis
Projects: Molecular Systems Biology
Investigation: Srimani et al (2017) Molecular Systems Biology
Biological problem addressed: Model Analysis Type
Organisms: No organisms
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Created: 26th Sep 2017 at 11:59
Last updated: 8th Nov 2017 at 15:21
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Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, School of Computer Science, University of Manchester, Stellenbosch University
https://orcid.org/0000-0003-2633-0537
The Molecular Systems Biology project holds information for reproducing simulation figures in the journal. This can include experimental data files, model files and manuscript information.
Programme: Journals
Public web page: http://msb.embopress.org
Drug detoxification dynamics explain the postantibiotic effect
Snapshots: No snapshots
After the removal of the extracellular antibiotic, efflux and inhibition dynamics combine to delay the synthesis of ribosomes in a concentration-dependent manner (panel ii). Colors indicate increasing antibiotic concentration, as shown in panel ii.
SED-ML simulation
https://jjj.bio.vu.nl/models/experiments/srimani2017_fig2cii/simulate
Person responsible: Dawie Van Niekerk
Snapshots: No snapshots
Creators: Dawie Van Niekerk, Jacky Snoep
Contributor: Dawie Van Niekerk
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: JWS Online
