Projects

Cyanobacteria are the only prokaryotes performing oxygenic photosynthesis. Theyhad and have tremendous influence on the biogeochemical cycles on Earth. Recently,cyanobacteria are increasingly investigated as cell factories for a sustainableeconomy. Despite their global, environmental and rising economic importance, ourknowledge on the regulation of their primary metabolism is fragmented.Cyanobacteria switch between photoautotrophic and heterotrophic modes ofmetabolism during day/night cycles or ...

Hypoglycaemia and lactic acidosis are key diagnostics for poor chances of survival in malaria patients. In this project we aim to test to what extent the metabolic activity of Plasmodium falciparum contributes to a changed glucose metabolism in malaria patients. The approach is to start with detailed bottom up models for the parasite and then merge these with more coarse grained models at the whole body level.

LEADER: StU (prof. B. Klumperman)

PARTNERS: StU & SU

OBJECTIVES:

• Optimization of antimalarial drug encapsulation for fast release.

• Development of transmission blocking drug encapsulation for slow release.

DELIVERABLES:

**07.2022 D ...

LEADER: prof. L-M. Birkholtz

PARTNERS: UP & WITS & SU & StU

OBJECTIVES:

• Evaluation of the ability of the novel polymer-drug systems to kill the transmissible gametocytes.

• Validation using treatment of anopheline mosquitoes in a membrane feeding assay.

...

LEADER: UL (prof. J.C. Simon)

PARTNERS: UL & IPF & SU & StU

OBJECTIVES:

• Validation of biocompatibility of the drug delivery systems with the skin.

• Testing of the drug delivery into and through the skin.

DELIVERABLES ...

LEADER: IPF (prof. A. Lederer)

PARTNERS: IPF & StU

OBJECTIVES:

• Determination of stability, degradation and drug release kinetics.

• Mathematical modelling of response to treatments of infectious diseases.

DELIVERABLES

10.2022 M 3.1 ...

Background- Thermophilic organisms are composed of both bacterial and archaeal species. The enzymes isolated from these species and from other extreme habitats are more robust to temperature, organic solvents and proteolysis. They often have unique substrate specificities and originate from novel metabolic pathways. Thermophiles as well as their stable enzymes (‘thermozymes’) are receiving increased attention for biotechnological applications.

The proposed project will establish thermophilic in ...

The main objectives of SysMO-DB are to: facilitate the web-based exchange of data between research groups within- and inter- consortia, and to provide an integrated platform for the dissemination of the results of the SysMO projects to the scientific community. We aim to devise a progressive and scalable solution to the data management needs of the SysMO initiative, that:

• facilitates and maximises the potential for data exchange between SysMO research groups;
• maximises the ‘shelf life’ and ...

Within the e:Bio - Innovationswettbewerb Systembiologie (Federal Ministry of Education and Research (BMBF)), the SulfoSYSBIOTECH consortium (10 partners), aim to unravel the complexity and regulation of the carbon metabolic network of the thermoacidophilic archaeon Sulfolobus solfataricus (optimal growth at 80°C and pH 3) in order to provide new catalysts ‘extremozymes’ for utilization in White Biotechnology.

Based on the available S. solfataricus genome scale metabolic model (Ulas et al., 2012) ...

Comparative Systems Biology: Lactic Acid Bacteria