Projects

What is a Project?
18 Projects found
No description specified

Up-regulation of glycolytic flux (glucose to lactate conversion), also known as the “Warburg effect”, has been associated with 90% of cancers. We implemented a systems biology approach in order to improve the overall understanding of the “Warburg effect” as well as identifying drug targets within the glycolytic pathway.

Programme: SARCHI: Mechanistic modelling of health and epidemiology

Public web page: Not specified

No description specified

Programme: SARCHI: Mechanistic modelling of health and epidemiology

Public web page: Not specified

No description specified

Programme: SARCHI: Mechanistic modelling of health and epidemiology

Public web page: Not specified

Hypoglycaemia and lactic acidosis are key diagnostics for poor chances of survival in malaria patients. In this project we aim to test to what extent the metabolic activity of Plasmodium falciparum contributes to a changed glucose metabolism in malaria patients. The approach is to start with detailed bottom up models for the parasite and then merge these with more coarse grained models at the whole body level.

The Molecular Systems Biology project holds information for reproducing simulation figures in the journal. This can include experimental data files, model files and manuscript information.

Programme: Journals

Public web page: http://msb.embopress.org

No description specified
No description specified
No description specified
No description specified
No description specified
No description specified
No description specified
No description specified
No description specified

The goal of the project is to establish a new biotechnological platform for the production of hydroxy-amino acids, since the current production of these important building blocks is very expensive. Enzyme engineering, systems biotechnology and metabolic engineering will be used in a synthetic biology approach.

Programme: SARCHI: Mechanistic modelling of health and epidemiology

Public web page: Not specified

LEADER: StU (prof. B. Klumperman)

PARTNERS: StU & SU


OBJECTIVES:

• Optimization of antimalarial drug encapsulation for fast release.

• Development of transmission blocking drug encapsulation for slow release.


DELIVERABLES:

**07.2022 D ...

Programme: M-era.Net 3D4D2

Public web page: Not specified

Start date: 1st Jul 2021

End date: 1st Jan 2024

Powered by
(v.1.14.2)
Copyright © 2008 - 2023 The University of Manchester and HITS gGmbH