Perfusion Analysis of Control group

The MRI Perfusion technique is FAIR, so three maps were calulated:

Selective Inversion T1 Map Global inversion T1 map Perfusion Map (ml/min/100g)

This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.

The** original Perfusion Map from the Bruker scanner** are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder pdata/ 1/ ...

Perfusion Analysis of Control group

The MRI Perfusion technique is FAIR, so three maps were calulated:

Selective Inversion T1 Map Global inversion T1 map Perfusion Map (ml/min/100g)

This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.

The** original Perfusion Map from the Bruker scanner** are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder pdata/ 1/ ...

Perfusion Analysis of Control group

The MRI Perfusion technique is FAIR, so three maps were calulated:

Selective Inversion T1 Map Global inversion T1 map Perfusion Map (ml/min/100g)

This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.

The** original Perfusion Map from the Bruker scanner** are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder pdata/ 1/ ...

Perfusion Analysis of Control group

The MRI Perfusion technique is FAIR, so three maps were calulated:

• Selective Inversion T1 Map
• Global inversion T1 map
• Perfusion Map (ml/min/100g)

This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.

The original Perfusion Map from the Bruker scanner are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder ...

PPK kinetic data for initial rate experiments and for enzyme incubations are linked and available in an Excel file. In addition a model file is available as Mathematica notebook for the parameterization of a rate equation for the enzyme, and for simulation of the enzyme incubations.

You will find the following here:

Data summary for all assays in the study

Graphpad Prism file for all figures + analyses

Cell line: Human aortic smooth muscel cells (Thermo Fisher Scientific, C-007-5C, LOT: 2164581)

Technical replicates: n=4 per condition

Conditions: C3 = TGFB1-treated SMCs C4 = PDGF-BB/IL1B-treated SMCs

Cell line: Human aortic smooth muscel cells (Thermo Fisher Scientific, C-007-5C, LOT: 2164581)

Technical replicates: n=4 per condition

Conditions: C3 = TGFB1-treated SMCs C4 = PDGF-BB/IL1B-treated SMCs

Majority direction kmer data files were used for the analysis. e.g: results/analysed_icg/xpore_cdna.all/diffmod_s1-s2/majority_direction_kmer_diffmod.table. which has been renamed to : s1_s2.table as uploaded here.