
Allosteric regulation of phosphofructokinase controls the emergence of glycolytic oscillations in isolated yeast cells

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SEEK ID: https://fairdomhub.org/studies/376
Glycolytic oscillations in individual isolated yeast cells
Projects: Yeast glycolytic oscillations
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Projects: Yeast glycolytic oscillations
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Created: 16th Jul 2018 at 16:09
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Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications, SCyCode The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers, Project Coordination, WP 3: Drug release kinetics study
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, University of Manchester - Department of Computer Science, Stellenbosch University
The currently used mathematical models for medical treatment at the individual or population level are largely phenomenological and have limited quantitative predictive power. It is usually not possible to predict the effect of an intervention in a specific process or to predict the effect of a pharmaceutical drug since the step or enzyme on which the intervention/drug works is not explicit in the model.
Taking HIV pathogenesis as an example, the immune system response, vaccine exposure, and drug ...
Projects: Whole body modelling of glucose metabolism in malaria patients, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications
Programme: SARCHI: Mechanistic modelling of health and epidemiology
Public web page: Not specified
Organisms: Saccharomyces cerevisiae
Submitter: Dawie van Niekerk
Studies: Allosteric regulation of phosphofructokinase controls the emergence of g..., Heterogeneity of glycolytic oscillatory behaviour in individual yeast cells, Sustained glycolytic oscillations in individual isolated yeast cells
Assays: gustavsson1-4 models, gustavsson5 model
Snapshots: No snapshots
Model of glycolytic oscillations in individual yeast cells in microfluidic flow chamber
Submitter: Dawie van Niekerk
Biological problem addressed: Model Analysis Type
Investigation: Glycolytic oscillations in individual isolated ...
Organisms: No organisms
Models: gustavsson5 model
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
Creators: Dawie van Niekerk, Jacky Snoep
Submitter: Dawie van Niekerk
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: JWS Online
Organism: Saccharomyces cerevisiae
Investigations: Glycolytic oscillations in individual isolated ...
Studies: Allosteric regulation of phosphofructokinase co...
Assays: gustavsson5 model
Abstract
Authors: Anna-Karin Gustavsson, David D. van Niekerk, Caroline B. Adiels, Bob Kooi, Mattias Goksör, Jacky L. Snoep
Date Published: 1st Jun 2014
Publication Type: Not specified
DOI: 10.1111/febs.12820
Citation: FEBS J 281(12) : 2784