On the function of the various quinone species in Escherichia coli


The respiratory chain of Escherichia coli contains three quinones. Menaquinone and demethylmenaquinone have low midpoint potentials and are involved in anaerobic respiration, while ubiquinone, which has a high midpoint potential, is involved in aerobic and nitrate respiration. Here, we report that demethylmenaquinone plays a role not only in trimethylaminooxide-, dimethylsulfoxide- and fumarate-dependent respiration, but also in aerobic respiration. Furthermore, we demonstrate that demethylmenaquinone serves as an electron acceptor for oxidation of succinate to fumarate, and that all three quinol oxidases of E. coli accept electrons from this naphtoquinone derivative.


Date Published: 1st Sep 2012

Authors: Poonam Sharma, Joost Teixeira De Mattos, Klaas J. Hellingwerf, Martijn Bekker

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Sharma, P., Teixeira de Mattos, M. J., Hellingwerf, K. J., & Bekker, M. (2012). On the function of the various quinone species inEscherichia coli. FEBS Journal, 279(18), 3364–3373. http://doi.org/10.1111/j.1742-4658.2012.08608.x

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Created: 14th Jan 2013 at 18:30

Last updated: 14th Jan 2013 at 18:30

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