Iterative cycles of model improvement and extension.

The output of the initial model of redox metabolism will be compared to experimental flux and metabolite data. Deviations between model and experiment will be prioritized together with WP2. We will apply Metabolic Control Analysis (Fell 1992 PMID: 1530563) to diagnose which enzymes control the deviating metabolite concentrations and/or rates. When the agreement between model and experiment is sufficient we will first link it to the existing model of trypanosome glycolysis and repeat the same quality control procedure. Further extensions of the network will be prioritized based experimental data analyses coming from WP1


Dynamic modelling of redox metabolism and gene expression

Projects: SilicoTryp

Study position:

Projects: SilicoTryp

Experimentalists: Jurgen Haanstra, Federico Rojas

help Creators and Submitter
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Views: 1415

Created: 29th Feb 2012 at 08:55

Last updated: 29th Feb 2012 at 11:13

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