Modelling of redox metabolism.

We are in the process of construct an ODE model of the trypanothione pathway. As input we will use newly determined and existing kinetic data and measured metabolite concentrations at the boundaries (from WP3&6). Recently the glycolysis model was extended with the pentose phosphate pathway. This pathway will yield the NAPDH that maintains trypanothione in a reduced state. For some complex enzymes (i.e trypanothione synthase) we are intensively discussing the kinetic data obtained on the isolated enzyme to formulate a biologically relevant rate equation


Dynamic modelling of redox metabolism and gene expression

Projects: SilicoTryp

Study position:

Projects: SilicoTryp

Experimentalists: Jurgen Haanstra, Alejandro Leroux, Dong-Hyun Kim

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Views: 1770

Created: 29th Feb 2012 at 08:52

Last updated: 29th Feb 2012 at 11:09

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