In vivo Nord 1: Chlorpyrifos-methyl

Aim: To investigate whether Atlantic cod that feed close to aquatic breeding facilities are affected by chlorpyrifos-methyl. Feeding experiment with chlorpyrifos-methyl, an organophosphorous pesticide detected in plant based salmon feed. Based on previous experiments using salmon.

Doses: 0, 0.5, 5.0, 25 mg/kg) chlorpyrifos-methyl. Duration: 30 days Set-up: Three tanks per treatment (12 in total)

Samples include: Liver, plasma, bile, brain. Analysis include:

  • Have RNAseq and metabolomics from 36 liver samples
  • Plasma cholinesterase, cortisol, ASAT, ALAT, and total protein (36 samples)
  • EROD on liver samples (36 samples)
  • Chemical levels of chlorpyrifos-methyl and main metabolite TCP in liver and bile (36 samples)
  • Hypoxia stress test (72 samples)

SEEK ID: https://fairdomhub.org/studies/593

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Projects: Systems toxicology of Atlantic cod

Study position:

Projects: Systems toxicology of Atlantic cod

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Citation
Eide, M. (2019). In vivo Nord 1: Chlorpyrifos-methyl. FAIRDOMHub. https://doi.org/10.15490/FAIRDOMHUB.1.STUDY.593.1
Note: This is a citation for Snapshot 1 of this Study, the contents of which may vary from what is shown on this page.
Snapshots
Snapshot 2 (30th May 2021)
Snapshot 1 (29th May 2019) DOI
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Created: 29th Apr 2019 at 16:58

Last updated: 26th May 2021 at 12:54

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