In vivo Nord 1: Chlorpyrifos-methyl

Aim: To investigate whether Atlantic cod that feed close to aquatic breeding facilities are affected by chlorpyrifos-methyl. Feeding experiment with chlorpyrifos-methyl, an organophosphorous pesticide detected in plant based salmon feed. Based on previous experiments using salmon.

Doses: 0, 0.5, 5.0, 25 mg/kg) chlorpyrifos-methyl. Duration: 30 days Set-up: Three tanks per treatment (12 in total)

Samples include: Liver, plasma, bile, brain. Analysis include:

  • Have RNAseq and metabolomics from 36 liver samples
  • Plasma cholinesterase, cortisol, ASAT, ALAT, and total protein (how many?)
  • EROD on liver samples (how many?)
  • Chemical levels of chlorpyrifos-methyl and main metabolite TCP in liver and bile (how many?)
  • Hypoxia stress test (how many?)

DOI: 10.15490/fairdomhub.1.study.593.1

Zenodo URL: None

Created at: 29th May 2019 at 13:28

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MD5: a753a1a6c13a94ccbb1934c518c6ac9c

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Citation
Eide, M. (2019). In vivo Nord 1: Chlorpyrifos-methyl. FAIRDOMHub. https://doi.org/10.15490/FAIRDOMHUB.1.STUDY.593.1
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Created: 29th May 2019 at 13:28

Last updated: 29th May 2019 at 13:28

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