Modeling the cell division cycle: cdc2 and cyclin interactions
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BiBTeXThe proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
SEEK ID: https://fairdomhub.org/publications/251
PubMed ID: 1831270
Projects: Kinetics on the move - Workshop 2016
Publication type: Not specified
Journal: Proc Natl Acad Sci U S A
Citation: Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7328-32.
Date Published: 15th Aug 1991
Registered Mode: Not specified
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Created: 26th May 2016 at 11:01
Last updated: 8th Dec 2022 at 17:26
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The German Network for Bioinformatics Infrastructure - de.NBI offers first class bioinformatics services including training and education to users in basic and applied life sciences research. In this network 40 projects belonging to eight service centers provide services that cover a wide variety of methods (genomics, proteomics, ...) and applications (from plants to humans). de.NBI-SysBio is the Systems Biology Service Center of de.NBI. In collaboration with FAIRDOM, de.NBI-SysBio serves the ...
Projects: de.NBI-SysBio, ExtremoPharm, ZucAt, Kinetics on the move - Workshop 2016, Example use cases, MIX-UP, Working Group Nicole Radde, MPIEvolBio-SciComp, SABIO-VIS
Web page: http://www.denbi.de
The workshop focuses on the publication, curation, retrieval, and usage of kinetic data from the reaction kinetics database SABIO-RK and on the use of data in modeling. There will be experience reports from scientists who successfully used experimental data to formulate or verify biological hypotheses with the computer, and you will experience how experimental data can be used with computational models.
Programme: de.NBI Systems Biology Service Center (de.NBI-SysBio)
Public web page: http://www.h-its.org/event/kinetics-on-the-move/
Submitter: Ron Henkel
Biological problem addressed: Cell Cycle
Investigation: Hands-on: Model Management in SEEK
Creators: Ron Henkel, Dagmar Waltemath
Submitter: Ron Henkel
This is BIOMD0000000005.
Creators: Ron Henkel, Dagmar Waltemath
Submitter: Ron Henkel
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: Copasi
