Transcription is the first step of gene expression and is characterized by a high fidelity of RNA synthesis. During transcription, the RNA polymerase active centre discriminates against not just non-complementary ribo NTP substrates but also against complementary 2'- and 3'-deoxy NTPs. A flexible domain of the RNA polymerase active centre, the Trigger Loop, was shown to play an important role in this process, but the mechanisms of this participation remained elusive.
PubMed ID: 20459653
Publication type: Not specified
Journal: BMC Biol.
Date Published: 1st Apr 2010
Registered Mode: Not specified
Created: 8th Feb 2011 at 12:52
Last updated: 8th Feb 2011 at 12:52