Stepwise mechanism for transcription fidelity

Abstract:

Transcription is the first step of gene expression and is characterized by a high fidelity of RNA synthesis. During transcription, the RNA polymerase active centre discriminates against not just non-complementary ribo NTP substrates but also against complementary 2'- and 3'-deoxy NTPs. A flexible domain of the RNA polymerase active centre, the Trigger Loop, was shown to play an important role in this process, but the mechanisms of this participation remained elusive.

SEEK ID: https://fairdomhub.org/publications/102

PubMed ID: 20459653

Projects: Noisy-Strep

Publication type: Not specified

Journal: BMC Biol.

Citation:

Date Published: 1st Apr 2010

Registered Mode: Not specified

Authors: , Aleksandra Bochkareva, Vasisht R Tadigotla, Mohammad Roghanian, Savva Zorov, Konstantin Severinov,

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Created: 8th Feb 2011 at 12:52

Last updated: 8th Feb 2011 at 12:52

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