Studies

5 Studies visible to you, out of a total of 5

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

Hi-IMPAcTB

Hannah P.Gideon, Travis K.Hughes, Constantine N.Tzouanas, Marc H.WadsworthII, Ang AndyTu, Todd M.Gierahn, Joshua M.Peters, Forrest F.Hopkins, Jun-RongWei, Conner Kummerlowe, Nicole L.Grant, Kievershen Nargan, Jia YaoPhuah, H. JacobBorish, Pauline Maiello, Alexander G.White, Caylin G.Winchell, Sarah K.Nyquist, Sharie Keanne C.Ganchua, Amy Myers, Kush V.Patel, Cassaundra L.Ameel, Catherine T.Cochran, Samira Ibrahim, Jaime A.Tomko, Lonnie JamesFrye, Jacob ...

Submitter: Dikshant Pradhan

Investigation: IMPAcTB

Assays: Immunohistochemistry – Data Linked, Library Creation – Metadata, NHP Necropsy – Metadata, PET-CT Scan Analysis – Data Linked, PET-CT Scan – Data Linked, Patient Visit – Metadata, Single Cell Clustering Analysis – Data Linked, Single Cell Expression Matrix Analysis – Data Linked, Single Cell Sequencing – Data Linked

Snapshots: Snapshot 1

Created: 20th May 2022 at 17:42, Last updated: 4th Aug 2023 at 14:56

Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

MIT SRP

Jennifer E. Kay, Joshua J. Corrigan, Amanda L. Armijo, Ilana S. Nazari, Ishwar N. Kohale, Dorothea K. Torous, Svetlana L. Avlasevich, Robert G. Croy, Dushan N. Wadduwage, Sebastian E. Carrasco, Stephen D. Dertinger, Forest M. White, John M. Essigmann, Leona D. Samson, Bevin P. Engelward

doi: https://doi.org/10.1101/2021.01.12.426356

Link to all of the Imaging done in this study: https://omero.mit.edu/webclient/?show=project-153 ...

Submitter: Dikshant Pradhan

Investigation: MIT SRP

Assays: GPT Assay – Data Attached, Mass Spectrometry Processing – Data Linked, Mass Spectrometry – Data Linked, Mouse Necropsy – Metadata, RaDR Image Machine Learning Analysis – Data Attached, Tissue Imaging – Metadata, Tissue Lysis – Metadata

Snapshots: Snapshot 1, Snapshot 2, Snapshot 3, Snapshot 4

DOI: 10.15490/fairdomhub.1.study.834.4

Created: 29th Mar 2021 at 16:34, Last updated: 4th Aug 2023 at 13:59

Immune cells in bronchoalveolar lavage fluid of Ugandan adults who resist versus those who develop latent Mycobacterium tuberculosis infection

Hi-IMPAcTB

Thiel BA, Worodria W, Nalukwago S, Nsereko M, Sanyu I, Rejani L, Zawedde J, Canaday DH, Stein CM, Chervenak KA, Malone LL, Kiyemba R, Silver RF, Johnson JL, Mayanja-Kizza H, Boom WH. Immune cells in bronchoalveolar lavage fluid of Ugandan adults who resist versus those who develop latent Mycobacterium tuberculosis infection. PLoS One. 2021 Apr 9;16(4):e0249477. doi: 10.1371/journal.pone.0249477. PMID: 33836031; PMCID: PMC8034721.

Abstract: ...

Submitter: Dikshant Pradhan

Investigation: IMPAcTB

Assays: Flow Cytometry Processing – Data Attached, Flow Cytometry – Data Linked, Patient Visit – Metadata, Tissue Collection - Metadata

Snapshots: Snapshot 1, Snapshot 2

DOI: 10.15490/fairdomhub.1.study.872.1

Created: 18th Oct 2021 at 14:01, Last updated: 15th May 2023 at 20:35

Fc-FcγR interactions shift alveolar macrophage metabolism to promote Mycobacterium tuberculosis restriction in mice

Hi-IMPAcTB

Submitter: Dikshant Pradhan

Investigation: IMPAcTB

Assays: Single Cell Sequencing Analysis – Data Linked, Single Cell Sequencing – Data Linked, Tissue Extraction – Metadata

Snapshots: Snapshot 1, Snapshot 2

Created: 9th Mar 2022 at 18:59, Last updated: 12th Apr 2023 at 20:20

Robust IgM responses following intravenous vaccination with Bacille Calmette-Guerin associate with prevention of Mycobacterium tuberculosis infection in macaques. Irvine et al (2021)

Hi-IMPAcTB

Development of an effective tuberculosis (TB) vaccine has suffered from an incomplete understanding of the correlates of protection against Mycobacterium tuberculosis (Mtb). Intravenous (i.v.) vaccination with Bacille Calmette–Guérin (BCG) provides nearly complete protection against TB in rhesus macaques, but the antibody response it elicits remains incompletely defined. Here we show that i.v. BCG drives superior antibody responses in the plasma and the lungs of rhesus macaques compared to ...

Submitter: Dikshant Pradhan

Investigation: IMPAcTB

Assays: Anti-Microbial Assay – Metadata, Functional Assay – Metadata, Luminex Assay – Metadata, Luminex Data Processing – Data Attached, NHP Tissue Collection – Metadata

Snapshots: Snapshot 1

Created: 25th Oct 2021 at 00:43, Last updated: 2nd Sep 2022 at 17:03

Studies

Filters ×

Filters