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HepG2 qPCR statistical significance, palmitate/low-glucose (Fig. S12)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

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Created: 9th May 2025 at 15:17, Last updated: 16th May 2025 at 11:45

Mice CoA biosynthetic intermediates (Fig. 4C)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: Mice (in vivo)

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Created: 9th May 2025 at 15:25, Last updated: 16th May 2025 at 11:45

Mice qPCR (Fig. 4E-F)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

The expression of various genes related to the CoA metabolism as measured by qPCR.

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: Mice (in vivo)

Download

Created: 16th May 2025 at 08:35, Last updated: 16th May 2025 at 11:45

HepG2 qPCR, palmitate/no-glucose (Fig. S9)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

Download

Created: 9th May 2025 at 15:09, Last updated: 16th May 2025 at 11:45

HepG2 qPCR, palmitate/low-glucose (Fig. S11)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

Download

Created: 9th May 2025 at 15:13, Last updated: 16th May 2025 at 11:45

HepG2 qPCR statistical significance, palmitate/no-glucose (Fig. S10)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

Download

Created: 9th May 2025 at 15:15, Last updated: 16th May 2025 at 11:45

HepG2 acylcarnitine measurements, palmitate/low-glucose (Fig. S5, Fig. S7)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

Download

Created: 9th May 2025 at 15:04, Last updated: 16th May 2025 at 11:45

HepG2 acyl-CoA/acylcarnitine measurements statistical significance, palmitate/low-glucose (Fig. S6)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

Download

Created: 9th May 2025 at 15:06, Last updated: 16th May 2025 at 11:45

HepG2 acyl-CoA/acylcarnitine measurements statistical significance, palmitate/no-glucose (Fig. S4)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

Download

Created: 9th May 2025 at 15:08, Last updated: 16th May 2025 at 11:45

HepG2 acyl-CoA measurements, palmitate/no-glucose (Fig. 2, Fig. S3, Fig. S7)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

Download

Created: 9th May 2025 at 14:55, Last updated: 16th May 2025 at 11:45

HepG2 CoA labelling data, palmitate/no-glucose (Fig. 3, Fig. S8, Tables S1-S4)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

Incorporation of stable isotope from pantothenate into total and free CoA pools.

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

Download

Created: 9th May 2025 at 15:00, Last updated: 16th May 2025 at 11:45

HepG2 acyl-CoA measurements, palmitate/low-glucose (Fig.S5, Fig. S7)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

Download

Created: 9th May 2025 at 15:02, Last updated: 16th May 2025 at 11:45

HepG2 acylcarnitine measurements, palmitate/no-glucose (Fig. 2, Fig. S2, Fig. S7)

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

No description specified

Creator: Christoff Odendaal

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Sequestration of CoA and adaptation of CoA meta...

Assays: HepG2 cells (in vitro)

Download

Created: 9th May 2025 at 14:53, Last updated: 16th May 2025 at 11:45

HepG2 protein concentration for O2 consumption assay

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

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Protein measurement used to normalised the oxygen consumption flux measured on an Oroboros oxygraph.

Creators: Christoff Odendaal, Barbara Bakker, Ligia Akemi Kiyuna, Albert Gerding; Nicolette Huijkman; Marcel Vieira-Lara; Anne-Claire Martines

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Model validation

Assays: HepG2 oxygen consumption

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Created: 7th Mar 2023 at 14:19, Last updated: 13th Jun 2023 at 14:53

Oxygen concentration and consumption flux in permeabilised HepG2 cells

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

(Show All)

Measured in an Oroboros oxygraph.

Creators: Christoff Odendaal, Barbara Bakker, Ligia Akemi Kiyuna, Albert Gerding; Nicolette Huijkman; Marcel Vieira-Lara; Anne-Claire Martines

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Model validation

Assays: HepG2 oxygen consumption

Download

Created: 7th Mar 2023 at 14:23, Last updated: 13th Jun 2023 at 14:53

Fibroblasts proteomics

PoLiMeR - Polymers in the Liver: Metabolism and Regulation

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Proteomics from MCADD and control individuals' fibroblasts.

Creators: Christoff Odendaal, Barbara Bakker, Emmalie Jager, Terry G.J. Derks, Karin Wolters; Anne-Claire Martines

Submitter: Christoff Odendaal

Investigations: Mitochondrial fatty acid oxidation in human liver

Studies: Model analysis

Assays: MCADD patient personalised modelling

Download

Created: 7th Mar 2023 at 13:49, Last updated: 13th Jun 2023 at 14:51

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