Mathematical Modelling of the Sporulation-Initiation Network in Bacillus Subtilis Revealing the Dual Role of the Putative Quorum-Sensing Signal Molecule PhrA Version 1
Simulate Model on JWSBacillus subtilis cells may opt to forgo normal cell division and instead form spores if subjected to certain environmental stimuli, for example nutrient deficiency or extreme temperature. The gene regulation net-work governing sporulation initiation accordingly incorporates a variety of signals and is of significant complexity. The present model (Bulletin of Mathematical Biology (2011) 73:181–211) includes four of these signals: nutrient levels, DNA damage, the products of the competence genes, and cell population size. An interesting prediction derived from the model is that PhrA, which is secreted from the cell and subsequently re-imported can act simultaneously as a quorum-sensing signal and as a timing mechanism, delaying sporulation when the cell has damaged DNA, possibly thereby allowing the cell time to repair its DNA before forming a spore.
Simulation link at JWS Online: http://jjj.mib.ac.uk/webMathematica/Examples/run.jsp?modelName=jabbari
SEEK ID: https://fairdomhub.org/models/59?version=1
1 item is associated with this Model:-
jabbari.dat (uuencoded file - 7.96 KB)
Organism: Clostridium acetobutylicum
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Execution or visualisation environment: JWS Online
Model image: No image specified
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Views: 4613 Downloads: 196
Created: 12th Oct 2011 at 11:56
Last updated: 7th Mar 2012 at 12:43
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Version 1 (earliest) Created 12th Oct 2011 at 11:56 by Franco du Preez
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Projects: SysMO DB
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester
Projects: COSMIC
Institutions: University of Nottingham
I'm an 'experimentalist' (molecular microbiologist) Postdoc working on regulation and peptide signaling in Clostridium acetobutylicum. I'm also a SysMO-DB PAL (Product Application Liason) for COSMIC, working on data management including standards and integration with SysMO SEEK.
Projects: COSMIC
Institutions: University of Nottingham
I am a Birmingham and MRC Fellow in mathematical biology. Specialising in the modelling of gene regulation networks using both numerical and analytical approaches, my work spans a range of biological applications, from drug development to bioenergy to understanding bacterial behaviour. My MRC fellowship gave me the opportunity to gain experimental training in order to generate the complementary data required to adopt a truly interdisciplinary approach to mathematical modelling in biology.
I worked ...
Projects: COSMIC
Institutions: University of Nottingham
I am a mathematical modeller concerned primarily with applications in biology,
SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".
The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.
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The main objectives of SysMO-DB are to: facilitate the web-based exchange of data between research groups within- and inter- consortia, and to provide an integrated platform for the dissemination of the results of the SysMO projects to the scientific community. We aim to devise a progressive and scalable solution to the data management needs of the SysMO initiative, that:
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Date Published: 21st Jul 2009
Publication Type: Not specified
