Mathematical Modelling of the Sporulation-Initiation Network in Bacillus Subtilis Revealing the Dual Role of the Putative Quorum-Sensing Signal Molecule PhrA
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Bacillus subtilis cells may opt to forgo normal cell division and instead form spores if subjected to certain environmental stimuli, for example nutrient deficiency or extreme temperature. The gene regulation net-work governing sporulation initiation accordingly incorporates a variety of signals and is of significant complexity. The present model (Bulletin of Mathematical Biology (2011) 73:181–211) includes four of these signals: nutrient levels, DNA damage, the products of the competence genes, and cell population size. An interesting prediction derived from the model is that PhrA, which is secreted from the cell and subsequently re-imported can act simultaneously as a quorum-sensing signal and as a timing mechanism, delaying sporulation when the cell has damaged DNA, possibly thereby allowing the cell time to repair its DNA before forming a spore.

Simulation link at JWS Online:


1 item is associated with this Model:
  • jabbari.dat (uuencoded file - 7.96 KB) Download

Organism: Clostridium acetobutylicum

Model type: Ordinary differential equations (ODE)

Model format: Not specified

Execution or visualisation environment: JWS Online

Model image: No image specified

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Views: 4617   Downloads: 196

Created: 12th Oct 2011 at 11:56

Last updated: 7th Mar 2012 at 12:43

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Version 1 (earliest) Created 12th Oct 2011 at 11:56 by Franco du Preez

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