An ODE model representing the metabolic network governing acid and solvent production by Clostridium acetobutylicum (Haus et al. BMC Systems Biology 2011, 5:10), incorporating the effect of pH upon gene regulation and subsequent end-product levels. This model describes the last of four experiments in which the pH of the culture was shifted. For this experiment the pH shift was reversed compared to the first three (shift from pH 4.5 to 5.7), with the pH control switched off after 129 hours.
Simulation link for JWS Online: http://jjj.mib.ac.uk/webMathematica/Examples/run.jsp?modelName=haus4
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Created: 12th Oct 2011 at 12:27
Last updated: 7th Mar 2012 at 13:48
Last used: 24th Sep 2017 at 23:34