Dynamic shift model of the effect of pH upon solvent production by Clostridium acetobutylicum - first experiment Version 1
Simulate Model on JWSAn ODE model representing the metabolic network governing acid and solvent production by Clostridium acetobutylicum (Haus et al. BMC Systems Biology 2011, 5:10), incorporating the effect of pH upon gene regulation and subsequent end-product levels. This model describes the first of four experiments in which the pH of the culture was shifted. For this experiment acidogenesis at pH 5.7 was maintained for 137 hours, after which the pH control was stopped, allowing the natural metabolic shift to the production of the solvents to begin.
Simulation link for JWS Online: http://jjj.mib.ac.uk/webMathematica/Examples/run.jsp?modelName=haus1
SEEK ID: https://fairdomhub.org/models/55?version=1
1 item is associated with this Model:-
haus1.dat (uuencoded file - 2.52 KB)
Organism: Clostridium acetobutylicum
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Execution or visualisation environment: JWS Online
Model image: No image specified
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Views: 4376 Downloads: 255 Runs: 0
Created: 12th Oct 2011 at 09:30
Last updated: 7th Mar 2012 at 12:45
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Version History
Version 1 (earliest) Created 12th Oct 2011 at 09:30 by Franco du Preez
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Projects: SysMO DB
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester
Projects: COSMIC
Institutions: University of Rostock
biomathematician, PhD student at the University of Rostock, Systems Biology Group Rostock
Projects: COSMIC
Institutions: University of Nottingham
I am a Birmingham and MRC Fellow in mathematical biology. Specialising in the modelling of gene regulation networks using both numerical and analytical approaches, my work spans a range of biological applications, from drug development to bioenergy to understanding bacterial behaviour. My MRC fellowship gave me the opportunity to gain experimental training in order to generate the complementary data required to adopt a truly interdisciplinary approach to mathematical modelling in biology.
I worked ...
SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".
The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.
Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...
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Programme: SysMO
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Date Published: 2011
Publication Type: Not specified
