WP4: Establishment of chemoenzymatic process
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Objectives: Establishment of the chemoenzymatic process with the best GO-ATA hybrid catalysts. Highlighting of the potential of the process in semi-preparative scale.
Description of Work: The best hybrid catalysts identified in WP3 will be investigated in coupled one-pot reactions selected in WP1, in batch and continuous flow reactors. The productivity of the system will be optimized with response surface methodology (RSM), for parameters such as temperature, duration, substrate concentration etc. The reusability of the system will be investigated, with specific focus on the recovery of the activity and potential reloading if required. The applicability will be highlighted in semi-preparative (mg) scale. The products will be characterized, and the isolated yield and purity of the one-pot process will be compared to a two-step batch process using the same catalysts.
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Created: 17th Apr 2020 at 19:26
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https://orcid.org/0000-0001-5811-368XAssist. Prof. of Enzyme Technology Laboratory, Department of Chemistry, University of Crete, Greece
The Hellenic Foundation for Research and Innovation is a new institution through which a profound reforming effort is being undertaken in the field of Research and Innovation in the country. The Organization supports unrestricted research (the systematic inquiry born of scientific curiosity) and new researchers by providing scholarships for doctoral candidates, as well as research projects for post-doctoral students, Researchers and Faculty Members. Through H.F.R.I., the research and academic ...
Web page: http://www.elidek.gr/en/homepage/
CEPOPA envisions a sustainable cascade one-pot process for the synthesis of optically pure amines from alcohols and/or alkynes, using enzymes immobilized onto catalytically active nanomaterials. In the framework of the project, efficient chemoenzymatic processes will be developed for the synthesis of a set of amines that can be used as building blocks for pharmaceuticals or biomaterials.
Programme: Hellenic Foundation for Research and Innovation - Supporting academic Staff and Researchers
Public web page: Not specified
Start date: 24th Feb 2020
End date: 23rd Aug 2023
