Neurospora Circadian Clock 3-variable model - PLM_51, version 1

 This model is derived from Biomodels 299 - the Leloup et al Neurospora clock model. This variant contains an embedded light-forcing function (SBO:000475) that provides a periodic light input. In this model, after 72h of LD12:12, the amplitude of Vs ( the light dependent parameter ) increases to 4.1, leading to chaotic oscillations. For this to happen, the periodic light function needs to produce a square-wave pattern.    Execution of this model will result in the behaviour depicted in Figure 2D of Gonze and Goldbeter (2000), 

Related Publications
Leloup JC, Gonze D, Goldbeter A. (1999). Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora.. J. Biol. Rhythms. Retrieved from:
Gonze, D and Goldbeter, A (2000). Entrainment Versus Chaos in a Model for a Circadian Oscillator Driven by Light-Dark Cycles. J. Stat Phys. Retrieved from:

Originally submitted to PLaSMo on 2012-02-01 22:35:07


Modelling Analysis

BioData SynthSys

Projects: PlaSMo model repository

Investigation: Adams, Richard

Study: Neurospora Circadian Clock 3-variable model - PLM_51

Biological problem addressed: Gene Regulatory Network

Organisms: No organisms

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Richard Adams

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Created: 10th Jan 2019 at 17:41

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