I am interested in the coupling of global regulation and metabolism in E. coli. To analyze this I construct and analyze defined mutant strains. These strains are characterized in bioreactor experiments of different types (batch, conti, pulse ...) and measurements on the level of metabolites, mRNA, and protein are applied. For all projects there are cooperation partners that use the data in modeling approaches either from the MPI Magdeburg or from the SUMO consortium.
Projects: SUMO
Institutions: University of Sheffield
Expertise: Microbiology, Biochemistry, Molecular Biology, Escherichia coli physiology, Bacterial Cell Biology, Regulatory Networks, Molecular microbiology, Cellular biology of metals
Tools: Microarray analysis, Molecular biology techniques (RNA/DNA/Protein), qRT-PCR, RNA / DNA Techniques, bacterial chemostat culture, Mutant and Strain Construction
Post-doctoral research associate working in Sheffield in the SUMO consortium.
Projects: PSYSMO, MOSES, COSMIC, BaCell-SysMO
Institutions: University of Stuttgart
Expertise: Reactor models, rapid sampling experiments, Systems Biology, Mathematical modeling, Regulatory Networks, Dynamics and Control of Biological Networks
Tools: Fermentation, stimulus response experiments, evaluation of process dynamics, continuous cultivation, Computational Systems Biology, including:- Dynamic modelling- Parameter estimation- Optimal experimental design- Dynamic optimization, Dynamic modelling, In silico Metabolic Network Analysis, fed-batch cultivation
Professor for Biochemcial Engineering, University Stuttgart
Projects: COSMIC
Institutions: University of Ulm
Expertise: Microbiology, Molecular Biology, Regulatory Networks
Tools: Fermentation, DNA, RNA, Proteins, Gaschromatography, Creation of Mutants
Dr. Bettina Schiel-Bengelsdorf Senior Scientist Department of Microbiology and Biotechnology University of Ulm 89069 Ulm, Germany
Projects: PSYSMO
Institutions: University of Braunschweig
Expertise: Microbiology, Molecular Biology, Transcriptomics, Anaerobic Microbiology, Bacterial metabolism | Metabolic engineering, Regulatory Networks
Tools: Genetics, Molecular Biology, Genetic modification, Microarray analysis, Proteomics (2D-PAGE), time lapse microscopy, Molecular biology techniques (RNA/DNA/Protein), qRT-PCR