Uncovering the Unusual Inhibition Mechanism of a Trypanosome Alternative Oxidase Inhibitor Displaying Broad-Spectrum Activity against African Animal Trypanosomes

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SEEK ID: https://fairdomhub.org/publications/780

DOI: 10.1021/acs.jmedchem.5c00631

Projects: WG1 - Compound libraries coordination and integration of compound design, WG2 - Integration of early phase studies and low environmental impact ac..., WG3 - Coordination of in vitro-to-in vivo translation of OneHealth leads..., WG4 - Integration of R&D process-environmental studies and translation i...

Publication type: Journal Article

Journal: Journal of Medicinal Chemistry

Book Title: Journal of Medicinal Chemistry

Publisher: American Chemical Society (ACS)

Citation: J. Med. Chem. 68(16):17155-17174.

Date Published: 4th Jun 2025

Registered Mode: by DOI

Authors: Godwin U. Ebiloma, Emmanuel O. Balogun, Natsumi Arai, Momoka Otani, Cecilia Baldassarri, Amani Alhejely, Eduardo Cueto-Díaz, Harry P. De Koning, Christophe Dardonville, Tomoo Shiba

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Ebiloma, G. U., Balogun, E. O., Arai, N., Otani, M., Baldassarri, C., Alhejely, A., Cueto-Díaz, E., De Koning, H. P., Dardonville, C., & Shiba, T. (2025). Uncovering the Unusual Inhibition Mechanism of a Trypanosome Alternative Oxidase Inhibitor Displaying Broad-Spectrum Activity against African Animal Trypanosomes. In Journal of Medicinal Chemistry (Vol. 68, Issue 16, pp. 17155–17174). American Chemical Society (ACS). https://doi.org/10.1021/acs.jmedchem.5c00631
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Created: 14th Jul 2026 at 08:18

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