DnaA and ORC: more than DNA replication initiators


Mutations in DNA replication initiator genes in both prokaryotes and eukaryotes lead to a pleiotropic array of phenotypes, including defects in chromosome segregation, cytokinesis, cell cycle regulation and gene expression. For years, it was not clear whether these diverse effects were indirect consequences of perturbed DNA replication, or whether they indicated that DNA replication initiator proteins had roles beyond their activity in initiating DNA synthesis. Recent work from a range of organisms has demonstrated that DNA replication initiator proteins play direct roles in many cellular processes, often functioning to coordinate the initiation of DNA replication with essential cell-cycle activities. The aim of this review is to highlight these new findings, focusing on the pathways and mechanisms utilized by DNA replication initiator proteins to carry out a diverse array of cellular functions.

SEEK ID: https://fairdomhub.org/publications/104

PubMed ID: 21123069

Projects: Noisy-Strep

Publication type: Not specified

Journal: Trends Cell Biol.


Date Published: 27th Aug 2010

Registered Mode: Not specified

Authors: Graham Scholefield, , Heath Murray

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Views: 3242

Created: 10th Feb 2011 at 11:25

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