T. brucei alpha-tubulins from neighboring protofilaments Version 1
Trypanosoma brucei multimeric alpha-tubulin protein receptor for docking studies, generated by alignment of two identical models of T. brucei alpha-tubulin on template 5ubq alpha-tubulin chains of two neighboring protofilaments (A, C).
SEEK ID: https://fairdomhub.org/data_files/6438?version=1
Filename:
tbrucei_alpha-tubulin-protofilament.pdb
Format: AportisDoc document
Size: 1.04 MB
Export PNG
Creators and Submitter
Views: 887 Downloads: 32
Created: 21st Apr 2023 at 17:20
Last updated: 24th Apr 2023 at 13:36
Tags AttributionsNone
Version History
Version 1 (earliest) Created 21st Apr 2023 at 17:20 by Ina Poehner
No revision comments
Related items
Projects: Kinetics on the move - Workshop 2016, COVID-19 Disease Map, NMTrypI - New Medicines for Trypanosomatidic Infections, CoVIDD - Coronavirus interactions in drug discovery - optimization and implementation
Institutions: Kinetics on the move Workshop at HITS, Heidelberg Institute for Theoretical Studies (HITS gGmbH), University of Eastern Finland (UEF)
https://orcid.org/0000-0002-2801-8902
Group Leader, Molecular and Cellular Modeling Group, EML Research, Heidelberg
Projects: NMTrypI - New Medicines for Trypanosomatidic Infections
Web page: https://cordis.europa.eu/programme/id/FP7_HEALTH.2013.2.3.4-2
The New Medicines for Trypanosomatidic Infections - NMTrypI project aimed at obtaining new candidate drugs against Trypanosomatidic infections with appropriate efficiency from the lead phase to the final preclinical phase that are more accessible to patients.
Programme: Drug development for neglected parasitic diseases
Public web page: https://fp7-nmtrypi.eu/
Start date: 1st Feb 2014
End date: 31st Jan 2017
Design, synthesis, computational studies and biological evaluation of antiparasitic dinitroaniline-ether phospholipid hybrids
Submitter: Ina Poehner
Studies: Computational identification of potential dinitroaniline binding sites i..., Docking studies of trifluraline and the dinitroaniline-etherphospholipid...
Assays: Comparative electrostatic analysis of dinitroaniline-sensitive and -resi..., Induced-fit docking studies, Multiple sequence alignment, Preparation of multimeric tubulin docking receptors
Induced fit docking studies of the dinitroaniline parent trifluraline and the newly designed dinitroaniline-etherphospholipid hybrids against different potential binding sites in monomeric and multimeric kinetoplastid tubulin receptors.
Submitter: Ina Poehner
Investigation: Antiparasitic dinitroaniline-ether phospholipid...
Assays: Induced-fit docking studies, Preparation of multimeric tubulin docking receptors
Prepared multimeric tubulin protein receptors for docking studies, generated by alignment of two identical models of alpha-tubulin on alpha-tubulin chains of two neighboring protofilaments.
Submitter: Ina Poehner
Biological problem addressed: Model Analysis Type
Investigation: Antiparasitic dinitroaniline-ether phospholipid...
