Alignments of various alpha-tubulin and beta-tubulin sequences from dinitroaniline-sensitive and dinitroaniline-resistant species. Sequences were retrieved from UniProt with the identifiers listed below and subjected to a multiple sequence alignment using ClustalOmega (ebi.ac.uk/Tools/msa/clustalo/; ClustalOmega webserver, last accessed 16-02-23):
alpha-tubulin:
- [dinitroaniline sensitive] T. cruzi - Q27352; T. brucei brucei - Q4GYY5; L. infantum - E9AGJ8; L. donovani - I3W8N6; L. major - Q4QGC5; T. gondii - P10873; P. falciparum - P14642; E. indica - O22347; C. reinhardtii - P09204; S. viridis - Q65C79; Z. mays - P14640; T. thermophila P41351
- [dinitroaniline resistant] H. sapiens - Q71U36; B. taurus - Q32KN8; S. scrofa - P02550; S. barbatus - A0A0R4I993; O. aries - D0VWZ0; R. norvegicus - P68370; G. gallus - P08070
- [Unknown] S. cerevisiae - P09733
beta-tubulin:
- [dinitroaniline sensitive] T. cruzi - Q8STF3; T. brucei brucei - Q4GYY6; L. infantum - A4HZJ3; L. donovani - I3W8N7; L. major - Q4QBZ6; T. gondii - P10878; P. falciparum - P14643; E. indica - Q9ZPP0; C. reinhardtii - P04690; S. viridis - Q65C77; Z. mays - P18025; T. thermophila P41352
- [dinitroaniline resistant] H. sapiens - Q9H4B7; B. taurus - Q2T9S0; S. scrofa - P02554; S. barbatus - A0A0R4I995; O. aries - W5PPT6; R. norvegicus - Q4QRB4; G. gallus - P32882
- [Unknown] S. cerevisiae - P02557
SEEK ID: https://fairdomhub.org/assays/2059
Modelling analysis
Projects: NMTrypI - New Medicines for Trypanosomatidic Infections
Investigation: Antiparasitic dinitroaniline-ether phospholipid hybrids
Assay position:
Biological problem addressed: Model Analysis Type
Organisms: Trypanosoma cruzi, Trypanosoma brucei, Leishmania infantum, Leishmania donovani, Leishmania major
Creators
Submitter
Views: 444
Created: 16th Feb 2023 at 11:20
Last updated: 24th Apr 2023 at 13:34