Archive of alpha-tubulin homology models Version 1
Collected PDB-files of homology models of alpha-tubulin, all based on T. thermophila tubulin PDB-ID 5ubq, chain A:
Includes models of the following dinitroaniline herbicide sensitive species (UniProt ID in brackets):
- C. reinhardtii (P09204)
- E. indica (O22347)
- L. donovani (I3W8N6)
- L. infantum (E9AGJ8)
- L. major (Q4QGC5)
- P. falciparum (P14642)
- S. viridis (Q65C79)
- T. brucei (Q4GYY5)
- T. cruzi (Q27352)
- T. gondii (P10873)
- Z. mays (P14640)
Includes models of the following dinitroaniline herbicide resistant species (UniProt ID in brackets):
- B. taurus (Q32KN8)
- G. gallus (P08070)
- H. sapiens (Q71U36)
- O. aries (D0VWZ0)
- R. norvegicus (P68370)
- S. barbatus (A0A0R4I993)
- S. scrofa (P02550)
Additionally, the archive includes (UniProt ID in brackets):
- S. cerevisiae (P09733; effect of dinitroaniline herbicides unclear)
- T. thermophila (P41351; template)
SEEK ID: https://fairdomhub.org/data_files/6321?version=1
Filename:
a-tubulin_homology_models.zip
Format: Zip file
Size: 1.92 MB
Export PNG
Creators and Submitter
Views: 543 Downloads: 18
Created: 22nd Feb 2023 at 10:46
Last updated: 24th Apr 2023 at 13:34
Tags AttributionsNone
Version History
Version 1 (earliest) Created 22nd Feb 2023 at 10:46 by Ina Poehner
No revision comments
Related items
Projects: Kinetics on the move - Workshop 2016, COVID-19 Disease Map, NMTrypI - New Medicines for Trypanosomatidic Infections, CoVIDD - Coronavirus interactions in drug discovery - optimization and implementation
Institutions: Kinetics on the move Workshop at HITS, Heidelberg Institute for Theoretical Studies (HITS gGmbH), University of Eastern Finland (UEF)
https://orcid.org/0000-0002-2801-8902
Group Leader, Molecular and Cellular Modeling Group, EML Research, Heidelberg
Projects: NMTrypI - New Medicines for Trypanosomatidic Infections
Web page: https://cordis.europa.eu/programme/id/FP7_HEALTH.2013.2.3.4-2
The New Medicines for Trypanosomatidic Infections - NMTrypI project aimed at obtaining new candidate drugs against Trypanosomatidic infections with appropriate efficiency from the lead phase to the final preclinical phase that are more accessible to patients.
Programme: Drug development for neglected parasitic diseases
Public web page: https://fp7-nmtrypi.eu/
Start date: 1st Feb 2014
End date: 31st Jan 2017
Design, synthesis, computational studies and biological evaluation of antiparasitic dinitroaniline-ether phospholipid hybrids
Submitter: Ina Poehner
Studies: Computational identification of potential dinitroaniline binding sites i..., Docking studies of trifluraline and the dinitroaniline-etherphospholipid...
Assays: Comparative electrostatic analysis of dinitroaniline-sensitive and -resi..., Induced-fit docking studies, Multiple sequence alignment, Preparation of multimeric tubulin docking receptors
Sequence and electrostatic potential analyses to identify sites in tubulins that differ between dinitroaniline-sensitive and dinitroaniline-resistant species.
Creation of homology models of various tubulins from dinitroaniline-sensitive and -resistant species, and a comparative analysis of their electrostatic potential grids overall and in putative binding site regions using PIPSA (Protein Interaction Property Similarity Analysis).
Submitter: Ina Poehner
Biological problem addressed: Model Analysis Type
Investigation: Antiparasitic dinitroaniline-ether phospholipid...
