ExploreDigitized pharmacokinetics data.
SEEK ID: https://fairdomhub.org/data_files/2992?version=1
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Kaplan1997.csv
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study dose time caf px tb tp Healy1991 250 0.25 1.73 0.1 0.19 Healy1991 250 0.5 6.64 0.67 0.25 Healy1991 250 0.75 6.25 0.76 0.27 Healy1991 250 1.0 5.85 0.92 0.3 Healy1991 250 1.5 5.44 1.1 0.31 0.12 Healy1991 250 2.0 5.14 1.16 0.26 0.13 Healy1991 250 2.5 4.63 1.26 0.33 0.14 Healy1991 250 3.0 4.19 1.3 0.33 0.14 Healy1991 250 4.0 3.48 1.43 0.37 0.15 Healy1991 250 5.0 2.96 1.48 0.41 0.16 Healy1991 250 6.0 2.44 1.42 0.4 0.16 Healy1991 250 8.0 1.88 1.33 0.44 0.17 Healy1991 500 0.25 9.12 0.38 0.29 Healy1991 500 0.5 16.49 0.98 0.34 Healy1991 500 0.75 14.31 1.01 0.32 0.12 Healy1991 500 1.0 13.81 1.32 0.38 0.14 Healy1991 500 1.5 12.03 1.62 0.46 0.17 Healy1991 500 2.0 10.43 1.84 0.5 0.19 Healy1991 500 2.5 9.81 2.07 0.52 0.21 Healy1991 500 3.0 9.58 2.32 0.55 0.23 Healy1991 500 4.0 7.78 2.6 0.6 0.25 Healy1991 500 5.0 6.48 2.7 0.66 0.28 Healy1991 500 6.0 5.8 2.77 0.66 0.27 Healy1991 500 8.0 4.42 2.73 0.69 0.29
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Created: 19th Jul 2019 at 13:58
Last updated: 19th Jul 2019 at 13:58
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Version 1 (earliest) Created 19th Jul 2019 at 13:58 by Matthias König
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Projects: Kinetics on the move - Workshop 2016, Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), FAIRDOM user meeting, COMBINE Multicellular Modelling, FAIRDOM & LiSyM & de.NBI Data Structuring Training
Institutions: Charité University Medicine Berlin, Humboldt-Universität zu Berlin, Humboldt University Berlin
https://orcid.org/0000-0003-1725-179X
We are investigating liver metabolism and function with the help of computational models and methods.
Group Leader Dr. Matthias König
Institute for Theoretical Biology Humboldt-University Berlin Philippstraße 13, 10115 Berlin, Germany phone +49 30 2093-98435 koenigmx@hu-berlin.de https://www.livermetabolism.com
The König group works on computational modeling, data science, data management, bioinformatics methods and machine learning on ...
LiSyM (Liver Systems Medicine) represents a research network of German centers and institutions, brought together by a 20 Million Euro funding program of the German Government, in which mathematicians, modelers, pharmacologists, molecular biologists and clinical scientists work together to develop a Systems Medicine approach to study early and advanced liver disease. The aim of this unique research program is to acquire and use new experimental data and data from existing data bases to build ...
Projects: Early Metabolic Injury (LiSyM-EMI - Pillar I), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), LiSyM Core Infrastructure and Management (LiSyM-PD), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), FAIRDOM & LiSyM & de.NBI Data Structuring Training, New LiSyM project
Web page: http://www.lisym.org
We will contribute to the LiSyM Research Network an open source, freely available and reproducible multiscale model of the human liver from single cell metabolism to whole liver function. The model will be available in existing standards of systems biology, provide standardized interfaces for data integration and be fully annotated to available biological, medical and computational ontologies. All data, models and source code will be shared within the LiSyM Research Network and made available to ...
Programme: LiSyM - Systems Medicine of the Liver
Public web page: https://livermetabolism.com
Understanding how liver function arises from the complex interaction of morphology, perfusion, and metabolism from single cells up to the entire organ requires systems-levels computational approaches.
Submitter: Matthias König
Studies: A Multiscale Computational Model of Human Galactose Metabolism, PKDB Caffeine Study
Assays: Digitized pharmacokinetics data (Akinyinka2000), Digitized pharmacokinetics data (Amchin1999), Digitized pharmacokinetics data (Blanchard1983a), Digitized pharmacokinetics data (Haller2002), Digitized pharmacokinetics data (Healy1991), Digitized pharmacokinetics data (Hetzler1990), Digitized pharmacokinetics data (Jeppesen1996), Digitized pharmacokinetics data (Kakuda2014), Digitized pharmacokinetics data (Kaplan1997), Digitized pharmacokinetics data (Magnusson2008), Digitized pharmacokinetics data (Oh2012), Digitized pharmacokinetics data (Perera2011), Digitized pharmacokinetics data (Spigset1999a), Digitized pharmacokinetics data (Tanaka2014), Galactose Modelling
Pharmacokinetics data set for caffeine
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Assays: Digitized pharmacokinetics data (Akinyinka2000), Digitized pharmacokinetics data (Amchin1999), Digitized pharmacokinetics data (Blanchard1983a), Digitized pharmacokinetics data (Haller2002), Digitized pharmacokinetics data (Healy1991), Digitized pharmacokinetics data (Hetzler1990), Digitized pharmacokinetics data (Jeppesen1996), Digitized pharmacokinetics data (Kakuda2014), Digitized pharmacokinetics data (Kaplan1997), Digitized pharmacokinetics data (Magnusson2008), Digitized pharmacokinetics data (Oh2012), Digitized pharmacokinetics data (Perera2011), Digitized pharmacokinetics data (Spigset1999a), Digitized pharmacokinetics data (Tanaka2014)
Data digitized from publication.
Kaplan1997 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
