PAH/PFAS mixture toxicity in vivo

BERGEN PUBLICATION Location: UiB Duration: 14 days, injections at day 0 and day 7 Sampling dates: 29-30 March 2017 Compounds tested: Polycyclic aromatic hydrocarbons (PAHs)/ Per- and polyfluoroalkyl substances (PFAS) No. of test groups: 10 No. of fish per group: 21-22 No. of dead fish:

Aim: *To investigate biological responses in Atlantic cod ( Gadus morhua) after in vivo exposure to a mixture of PAHs and PFASs, either singly or combined, at low (1x) or high (20x) doses. *PFAS concentrations were determined in cod liver, and PAH metabolites were measured in bile as a biomarker of PAH exposure. *Various biomarkers were determined at transcript and protein levels in the liver, and lipidomics and proteomics analyses were performed on liver tissue to study responses on lipid metabolism.

SEEK ID: https://fairdomhub.org/studies/753

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Projects: Systems toxicology of Atlantic cod

Study position:

Projects: Systems toxicology of Atlantic cod

Experimentalists: Karina Dale, Fekadu Yadetie, Roger Lille-Langøy, Anders Goksøyr, Odd André Karlsen, Essa Khan, Ane Haarr, Zhanna Tairova, Mette Bjørge Müller, Jan Ludvig Lyche

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Dale, K. (2020). PAH/PFAS mixture toxicity in vivo. FAIRDOMHub. https://doi.org/10.15490/FAIRDOMHUB.1.STUDY.753.2
Note: This is a citation for Snapshot 2 of this Study, the contents of which may vary from what is shown on this page.
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Created: 28th Apr 2020 at 12:01

Last updated: 3rd Jul 2020 at 10:07

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