PAH/PFAS mixture toxicity in vivo

BERGEN PUBLICATION Location: UiB Duration: 14 days, injections at day 0 and day 7 Sampling dates: 29-30 March 2017 Compounds tested: Polycyclic aromatic hydrocarbons (PAHs)/ Per- and polyfluoroalkyl substances (PFAS) No. of test groups: 10 No. of fish per group: 21-22 No. of dead fish:

Aim: *To investigate biological responses in Atlantic cod ( Gadus morhua) after in vivo exposure to a mixture of PAHs and PFASs, either singly or combined, at low (1x) or high (20x) doses. *PFAS concentrations were determined in cod liver, and PAH metabolites were measured in bile as a biomarker of PAH exposure. *Various biomarkers were determined at transcript and protein levels in the liver, and lipidomics and proteomics analyses were performed on liver tissue to study responses on lipid metabolism.


hidden item

Projects: Systems toxicology of Atlantic cod

Study position:

Projects: Systems toxicology of Atlantic cod

Experimentalists: Karina Dale, Fekadu Yadetie, Roger Lille-Langøy, Anders Goksøyr, Odd André Karlsen, Essa Khan, Ane Haarr, Zhanna Tairova, Mette Bjørge Müller, Jan Ludvig Lyche

help Creators and Submitter
Dale, K. (2020). PAH/PFAS mixture toxicity in vivo. FAIRDOMHub.
Note: This is a citation for Snapshot 2 of this Study, the contents of which may vary from what is shown on this page.
Snapshot 2 (7th Jul 2020) DOI
Snapshot 1 (7th Jul 2020) DOI

Views: 600

Created: 28th Apr 2020 at 12:01

Last updated: 3rd Jul 2020 at 10:07

Powered by
Copyright © 2008 - 2022 The University of Manchester and HITS gGmbH

By continuing to use this site you agree to the use of cookies