Mean normalized expression (MNE) levels of cyp1a and acox1 measured in liver of Atlantic Cod exposed to PAH and PFAS mixtures
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Created: 28th Apr 2020 at 10:19
Last updated: 3rd Jul 2020 at 08:08
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Version 1 (earliest) Created 28th Apr 2020 at 10:19 by Karina Dale
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Projects: Systems toxicology of Atlantic cod
Institutions: University of Bergen
Expertise: Molecular Biology
The goal of the dCod-project is to combine the competencies in environmental toxicology, biology, bioinformatics and mathematics across the traditional department boundaries, to create a deeper understanding of cods' adaptations and reactions to stressors in the environment. Building on the thoroughly studies and mapping of the cod genome at UiO and the long research traditions on cod at the Department of Biology at UiB, the dCod project will expand our knowledge with methods based on genomics; ...
Projects: Systems toxicology of Atlantic cod
Web page: http://dcod.no
Coastal zones and oceans constitute an essential fundament for Norway’s history as well as current economy, providing ecosystem services for fisheries, aquaculture, transport, tourism, and recreation. The petroleum activities in Norwegian waters have been crucial for Norway’s financial growth and in financing the Norwegian welfare state. As the pressure on the oceans continuously increases, both the petroleum industry and the seafood industries have acknowledged that awareness and actions are ...
Programme: dCod 1.0: decoding systems toxicology of cod
Public web page: http://www.uib.no/en/dcod
Organisms: Gadus morhua
BERGEN PUBLICATION Location: UiB Duration: 14 days, injections at day 0 and day 7 Sampling dates: 29-30 March 2017 Compounds tested: Polycyclic aromatic hydrocarbons (PAHs)/ Per- and polyfluoroalkyl substances (PFAS) No. of test groups: 10 No. of fish per group: 21-22 No. of dead fish:
Aim: *To investigate biological responses in Atlantic cod ( Gadus morhua) after in vivo exposure to a mixture of PAHs and PFASs, either singly or combined, at low (1x) or high (20x) doses. *PFAS concentrations were ...
Submitter: Karina Dale
Investigation: 1 hidden item
Assays: Chemical analyses, Comet Assay, ELISA Cyp1a liver, Enzyme activity assays, Fish biometrics in vivo I, Lipidomics, Liver gene expression (qPCR), Proteomics, Vitellogenin in plasma
Snapshots: Snapshot 1, Snapshot 2
Gene expression of cyp1a and acox1 measured by qPCR in liver of Atlantic cod exposed to PAHs and PFASs
Submitter: Karina Dale
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: 1 hidden item
Organisms: Gadus morhua
SOPs: No SOPs
Data files: In vivo-1 biometrics, Liver gene expression cyp1a and acox1
Snapshots: No snapshots