Virus structure and structure-based antivirals

Abstract:

Structure-based antiviral developments in the past two years have been dominated by the structure determination and inhibition of SARS-CoV-2 proteins and new lead molecules for picornaviruses. The SARS-CoV-2 spike protein has been targeted successfully with antibodies, nanobodies, and receptor protein mimics effectively blocking receptor binding or fusion. The two most promising non-structural proteins sharing strong structural and functional conservation across virus families are the main protease and the RNA-dependent RNA polymerase, for which design and reuse of broad range inhibitors already approved for use has been an attractive avenue. For picornaviruses, the increasing recognition of the transient expansion of the capsid as a critical transition towards RNA release has been targeted through a newly identified, apparently widely conserved, druggable, interprotomer pocket preventing viral entry. We summarize some of the key papers in these areas and ponder the practical uses and contributions of molecular modeling alongside empirical structure determination.

Citation: Current Opinion in Virology 51:16-24

Date Published: 1st Dec 2021

Registered Mode: by DOI

Authors: Zlatka Plavec, Ina Pöhner, Antti Poso, Sarah J Butcher

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Citation
Plavec, Z., Pöhner, I., Poso, A., & Butcher, S. J. (2021). Virus structure and structure-based antivirals. In Current Opinion in Virology (Vol. 51, pp. 16–24). Elsevier BV. https://doi.org/10.1016/j.coviro.2021.09.005
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Created: 24th Sep 2021 at 13:11

Last updated: 24th Sep 2021 at 13:14

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