Presentations

An overview of the SEEK for the HCLS Systems Biology Task force meeting

Presentation on project progress - meeting Berlin April 5th 2012

This presentation gives an overview of the way we structure and share data in the SEEK using JERM templates, and how we use the ISA hierarchy of Investigations, Studies, and Assays to associate experiments and data sets together. These slides were presented at the SEEK Users meeting in Berlin 2012.

Slide for an overview of new, and future upcoming features being developed in SEEK - presented at the Berlin SEEK Users Meeting March 2012.

This presentation given at the 5th International Beilstein Symposium presents the development of a model for the pH-induced shift in C. acetobutylicum. Starting from experimental information, the model construction and underlying assumptions are explained. Furthermore, the required additions to the metabolic and genetic network caused by the used experimentals setup are established.

The established metabolic and genetic model is compared to dynamic shift experiments starting at acidogenesis and ...

Oral presentation given at ICSB 2011 in Mannheim/Heidelberg

Presentation of JERM and new Master templates by Olga Krebs at SySMO PALs meeting in Heidelberg on 27th of August 2011

The presentation of new features in SEEK at last PALs meeing in Heidelberg on 27th of August by David, Lihua and Quyen

In the talk I show that an increase in the concentration of one of two channelling enzyme has no effect on the flux. In contrast a decrease in the concentration of one of two channelling enzymes has the same effect like a concentration decrease of both enzymes.

Presentation given by Colin Harwood presenting results about ITC experiments to confirm interactions. Preliminary crystallisation experiments commenced on suitable candidates.

The talk shows that proline biosynthesis and accumulation is connected to glycine betaine availability. Glycine betaine complements proline function.

The talk shows that position 153 in various glutamate-kinases regulates proline feed-back regulation. This difference is shown for ProB being proline sensitivie and ProJ being proline independent.

Michael Kohlstedt presented flux data as integrated output of cellular components. Moreover, proteomics and metabolomics data reveal significant changes in intracellular protein and metabolite level and osmoprotection (supplementing glycine betaine) creates a novel metabolic state.

Presentation by Thomas Millat of a tool for automatized analysis of flow cytometry data. It allows characterisation of different growth modalities, statistical measures of mean and variance and estimation of population overlap all along with appropriate visualization.

Poster presented during the ICSB 2011 conference in Mannheim

The image file represents the activation of sigB in response to glucose starvation. It was drawn alongside the model 'sigb-response_starvation_shakeflask'. Biomass catalyses the conversion of glucose to biomass, while a low glucose concentration will negatively affect cell viability (inverted shown in the figure, where Glc inhibits cell death). W (RsbW) can form dimers with sigB (B) and dimers and trimers with V (RsbV)(WV, WV2) and is able to phosphorylate V to VP. A high glucose concentration ...