Investigations
What is an Investigation?
Submitter: Jurgen Haanstra
Studies: Inhibition with Sulfasalazine (SSZ), Measurements of metabolism of HepG2 cells at 0 mM, 6 mM or 22 mM externa..., protein per cell for HepG2 cells
Assays: Cell counts and BCA Protein, Cell counts and metabolite levels, Inhibition experiment for the effect of SSZ on HepG2 metabolism
Aim. Constructing a predictive, dynamic model of the redox metabolism of trypanosomes. Aided by this model we will quantify the impact of gene-expression and metabolic regulation on redox metabolism. The model will be constructed in an iterative cycle of experimentation – modelling – analysis – experimentation, such that it can be extended and refined based on new experimental insights.
Submitter: Jurgen Haanstra
Studies: Iterative cycles of model improvement and extension., Modelling of gene expression and Regulation Analysis., Modelling of redox metabolism.
Assays: No Assays
