SEEK ID: https://fairdomhub.org/investigations/214
Projects: Yeast glycolytic oscillations
Investigation position:
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Created: 17th Jul 2018 at 09:13
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Projects: PSYSMO, MOSES, SysMO DB, SysMO-LAB, SulfoSys, SulfoSys - Biotec, Whole body modelling of glucose metabolism in malaria patients, FAIRDOM, Molecular Systems Biology, COMBINE Multicellular Modelling, HOTSOLUTE, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications, SCyCode The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers, Project Coordination, WP 3: Drug release kinetics study
Institutions: Manchester Centre for Integrative Systems Biology, University of Manchester, University of Stellenbosch, University of Manchester - Department of Computer Science, Stellenbosch University
The currently used mathematical models for medical treatment at the individual or population level are largely phenomenological and have limited quantitative predictive power. It is usually not possible to predict the effect of an intervention in a specific process or to predict the effect of a pharmaceutical drug since the step or enzyme on which the intervention/drug works is not explicit in the model.
Taking HIV pathogenesis as an example, the immune system response, vaccine exposure, and drug ...
Projects: Whole body modelling of glucose metabolism in malaria patients, Steroid biosynthesis, Yeast glycolytic oscillations, Computational pathway design for biotechnological applications
Programme: SARCHI: Mechanistic modelling of health and epidemiology
Public web page: Not specified
Organisms: Saccharomyces cerevisiae
Submitter: Dawie van Niekerk
Investigation: From steady-state to synchronized yeast glycoly...
Assays: No Assays
Snapshots: No snapshots
Submitter: Dawie van Niekerk
Investigation: From steady-state to synchronized yeast glycoly...
Assays: No Assays
Snapshots: No snapshots
Abstract (Expand)
Authors: F. B. du Preez, D. D. van Niekerk, J. L. Snoep
Date Published: No date defined
Publication Type: Not specified
PubMed ID: 22686585
Citation: FEBS J. 2012 Aug;279(16):2823-36. doi: 10.1111/j.1742-4658.2012.08658.x. Epub 2012 Jul 5.
Abstract (Expand)
Authors: F. B. du Preez, D. D. van Niekerk, B. Kooi, J. M. Rohwer, J. L. Snoep
Date Published: No date defined
Publication Type: Not specified
PubMed ID: 22712534
Citation: FEBS J. 2012 Aug;279(16):2810-22. doi: 10.1111/j.1742-4658.2012.08665.x. Epub 2012 Jul 9.