Systems Biology is one of the most prominent newly emerging interdisciplinary science areas. By connecting fields such as genomics, proteomics, cell biology, medicine, molecular biology, biochemistry and genetics, with mathematics, bioinformatics, engineering and computation, it enables discovery of yet unknown principles underlying the functioning of living cells. At the same time testable and predictive models of complex cellular pathways and eventually of whole cells are generated, which are useful for efficient experimental design and bioengineering and the network-based design of drugs and therapies. This advanced lecture course will cover essential and state-of-the-art aspects of SysBio from principles and methods through the modeling of living systems to applications in biotechnology and medicine. Course opens the doors for regular student training in Systems Biology in Europe, provide a basis for a human network of young Systems Biology experts, and provide a centre for other Systems Biology discussions between scientists and funders. SysMO DB team will represent Data mangement in praxis.