Biological problem addressed 'Metabolism'

Modelling the degradation of BPG, GAP and DHAP at high temperature

Despite high similarity in sequence and catalytic properties, the L-lactate dehydrogenases (LDH) in lactic acid bacteria (LAB) display differences in their regulation which may arise from their adaptation to different habitats. We combined experimental and computational approaches to investigate the effects of fructose-1,6-bisphosphate (FBP), phosphate (Pi) and ionic strength (NaCl concentration) on 6 LDHs from 4 LABs studied at pH 6 and pH 7. We find: (1) The extent of activation by FBP (Kact) ...

The spatio-temporal model that allows investigating the structure of glycogen in three dimensions . The model is based on a stochastic process that simulates the key enzymatic steps. The model is designed to track the position of all glucose units in time together with the activities of the enzymatic reactions. The four main reactions involved in synthesis and degradation (catalysed by Glycogen Synthase - GYS, Glycogen Branching Enzyme - GBE, Glycogen Phosphorylase – GLP - and Glycogen Debranching ...