In vivo II -WY and GW biometrics
8 June 2017
19 June 2017
Control 1
Saline/kolliphore/DMSO
Not specified
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192
28
M
7.6
Not specified
0.8746355685131195
3.958333333333333
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Created: 3rd Mar 2022 at 11:31
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Projects: Systems toxicology of Atlantic cod, DigiSal
Institutions: University of Bergen
Expertise: exposure studies, ex vivo, in vivo, genome mining
The goal of the dCod-project is to combine the competencies in environmental toxicology, biology, bioinformatics and mathematics across the traditional department boundaries, to create a deeper understanding of cods' adaptations and reactions to stressors in the environment. Building on the thoroughly studies and mapping of the cod genome at UiO and the long research traditions on cod at the Department of Biology at UiB, the dCod project will expand our knowledge with methods based on genomics; ...
Projects: Systems toxicology of Atlantic cod
Web page: http://dcod.no
Coastal zones and oceans constitute an essential fundament for Norway’s history as well as current economy, providing ecosystem services for fisheries, aquaculture, transport, tourism, and recreation. The petroleum activities in Norwegian waters have been crucial for Norway’s financial growth and in financing the Norwegian welfare state. As the pressure on the oceans continuously increases, both the petroleum industry and the seafood industries have acknowledged that awareness and actions are ...
Programme: dCod 1.0: decoding systems toxicology of cod
Public web page: http://www.uib.no/en/dcod
Organisms: Gadus morhua
Location: UiB Date: 8-20 June 2017 Compounds tested: WY-14,643 (PPAR alpha agonist), GW501516 (PPAR beta agonist) No. of test groups: 5 (Control 1: DMSO/saline/PEG, WY-14.643 High (40 mg/kg), WY-14.643 Low (4.0 mg/kg), GW501516 High (4.0 mg/kg), GW501516 Low (0.4 mg/kg)) No. of fish per group: 22
Aim: *To investigate effects on lipid metabolism in Atlantic cod ( Gadus morhua) mediated by peroxisome proliferator-activated receptors (Ppars) by in vivo exposure to two mammalian PPAR agonists.
Submitter: Marta Eide
Investigation: 1 hidden item
Assays: In vivo II - GW and WY Biometric data, Proteomics data, RNA sequencing, Targeted lipidomics, Untargeted lipidomics
Snapshots: Snapshot 1, Snapshot 2, Snapshot 3
Submitter: Marta Eide
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: 1 hidden item
Organisms: No organisms
SOPs: No SOPs
Data files: In vivo II -WY and GW biometrics
Snapshots: No snapshots
Untargeted lipidomics analysis was performed on plasma and liver samples of four male fish from each group (n = 4) at Per Bruheim’s lab at NTNU, Norway, using Liquid Chromatography Hybrid Quadrupole Mass Spectrometry (UPLC-HDMS).
Submitter: Marta Eide
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: 1 hidden item
Organisms: No organisms
SOPs: No SOPs
Data files: Compound measurements from liver, Compound measurements from plasma, Untargeted liver lipid analysis_normalized values
Snapshots: Snapshot 1
Biometric data from in vivo II experiment
Investigations: 1 hidden item
Fish ID (Integer) *, Date start (Date) , Date sampling (Date) , Exposure compound (String) , Exposure dose (String) , Tank/group (Integer) , Exposure time (day) (Integer) , Weight (g) (Real number) , Length (cm) (Real number) , Gender (F/M) (String) , Liver weight (g) (Real number) , Gonade weight (g) (Real number) , Condition factor (CF) (Real number) , Hepatosomatic index (HSI) (Real number) , Gonadosomatic index (GSI) (Real number) , Gross pathology (String)
Not specified