The chemical defensome of five model teleost fish

Abstract:

How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify and eliminate chemical stressors. This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome. Teleost fish is the largest group of vertebrate species and can provide valuable insights into the evolution and functional diversity of defensome genes. We have previously shown that the xenosensing pregnane x receptor (pxr, nr1i2) is lost in many teleost species, including Atlantic cod (Gadus morhua) and three-spined stickleback (Gasterosteus aculeatus), but it is not known if compensatory mechanisms or signaling pathways have evolved in its absence. In this study, we compared the genes comprising the chemical defensome of five fish species that span the teleosteii evolutionary branch often used as model species in toxicological studies and environmental monitoring programs: zebrafish (Danio rerio), medaka (Oryzias latipes), Atlantic killifish (Fundulus heteroclitus), Atlantic cod, and three-spined stickleback. Genome mining revealed evolved differences in the number and composition of defensome genes that can have implication for how these species sense and respond to environmental pollutants, but we did not observe any candidates of compensatory mechanisms or pathways in cod and stickleback in the absence of pxr. The results indicate that knowledge regarding the diversity and function of the defensome will be important for toxicological testing and risk assessment studies.

SEEK ID: https://fairdomhub.org/publications/603

DOI: 10.1038/s41598-021-89948-0

Projects: Systems toxicology of Atlantic cod

Publication type: Journal

Journal: Scientific Reports

Citation: Sci Rep 11(1),10546

Date Published: 1st Dec 2021

Registered Mode: by DOI

Authors: Marta Eide, Xiaokang Zhang, Odd André Karlsen, Jared V. Goldstone, John Stegeman, Inge Jonassen, Anders Goksøyr

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Citation
Eide, M., Zhang, X., Karlsen, O. A., Goldstone, J. V., Stegeman, J., Jonassen, I., & Goksøyr, A. (2021). The chemical defensome of five model teleost fish. In Scientific Reports (Vol. 11, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41598-021-89948-0
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Created: 19th May 2021 at 09:14

Last updated: 19th May 2021 at 09:17

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