Coronavirus infections and immune responses

Abstract:

Coronaviruses (CoVs) are by far the largest group of known positive-sense RNA viruses having an extensive range of natural hosts. In the past few decades, newly evolved Coronaviruses have posed a global threat to public health. The immune response is essential to control and eliminate CoV infections, however, maladjusted immune responses may result in immunopathology and impaired pulmonary gas exchange. Gaining a deeper understanding of the interaction between Coronaviruses and the innate immune systems of the hosts may shed light on the development and persistence of inflammation in the lungs and hopefully can reduce the risk of lung inflammation caused by CoVs. In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV-induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment.

SEEK ID: https://fairdomhub.org/publications/513

DOI: 10.1002/jmv.25685

Projects: COVID-19 Disease Map

Publication type: Journal

Journal: Journal of Medical Virology

Citation: J Med Virol 92(4):424-432

Date Published: 7th Feb 2020

URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25685

Registered Mode: imported from a bibtex file

Authors: Geng Li, Yaohua Fan, Yanni Lai, Tiantian Han, Zonghui Li, Peiwen Zhou, Pan Pan, Wenbiao Wang, Dingwen Hu, Xiaohong Liu, Qiwei Zhang, Jianguo Wu

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Citation
Li, G., Fan, Y., Lai, Y., Han, T., Li, Z., Zhou, P., Pan, P., Wang, W., Hu, D., Liu, X., Zhang, Q., & Wu, J. (2020). Coronavirus infections and immune responses. In Journal of Medical Virology (Vol. 92, Issue 4, pp. 424–432). Wiley. https://doi.org/10.1002/jmv.25685
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Created: 8th Apr 2020 at 20:13

Last updated: 8th Dec 2022 at 17:26

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